病毒学与生物学相关资源

• 最新！新型冠状病毒毒种电镜照片发布
• 就在武汉，中科院团队揭示蝙蝠可能为新型冠状病毒宿主
• 来了！新型肺炎冠状病毒3CL水解酶高分辨率晶体结构图
• 好消息！中国疾控中心成功分离我国首株新型冠状病毒毒种
• Clock and TMRCA based on 27 genomes
• 柳叶刀最新论文：2019-nCoV的基因组序列与人类SARS病毒不同
• Nature突破 | 证实SARS元凶是蝙蝠的武汉病毒所石正丽团队再出手，表明武汉新冠病毒最可能宿主还是蝙蝠
• A pneumonia outbreak associated with a new coronavirus of probable bat origin
• Cell子刊 | 新发现，中国学者揭示2019-nCoV与SARS 的不同点，有助于了解2019-nCoV的真正起源和演变！
• Genome Composition and Divergence of the Novel Coronavirus (2019-nCoV) Originating in China
• 正式命名来了 | 世界卫生组织将新型冠状病毒命名为COVID-19
• 官方发布：新冠病毒被命名为SARS-CoV-2，疾病名称为COVID-19
• 突破 | 横跨15年，3篇Nature/Science，石正丽等团队发现蝙蝠是SARS，猪急性腹泻及新型冠状肺炎的病原体的宿主
• Bats Are Natural Reservoirs of SARS-Like Coronaviruses
• Fatal swine acute diarrhoea syndrome caused by an HKU2-related coronavirus of bat origin
• 超强传染力：新型冠状肺炎病毒S蛋白与受体的结合强度是SARS的10多倍！
• Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation
• SARS-CoV-2？新冠病毒、SARS冠状病毒、SARS相关冠状病毒，它们之间是什么关系？
• Structure of dimeric full-length human ACE2 in complex with B0AT1
• 最新研究：华南海鲜市场非新冠病毒起源地，11月中下旬已人传人
• Decoding the evolution and transmissions of the novel pneumonia coronavirus (SARS-CoV-2) using whole genomic data
• 中科院通过全基因组数据解析，证实华南海鲜市场并非病毒源头
• 人造论再次被否！新冠病毒的产生可追溯至 2009 年，SARS 期间或获得感染能力
• Recombination and convergent evolution led to the emergence of 2019 Wuhan coronavirus
• 新思路 | 应对新冠肺炎病毒变异，哈佛学者首次提出以毒攻毒策略：基因编辑技术会大放异彩
• Virus against virus: a potential treatment for 2019-nCov (SARS-CoV-2) and other RNA viruses
• Lancet最新 | 高福/石正丽等呼吁新冠病毒需要改名！建议改为人冠状病毒2019
• A distinct name is needed for the new coronavirus
• Science | 罕见，投稿到接受只用了9天！2019-nCoV S蛋白结构被解析
• Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation
• 再添力证，还是穿山甲！管轶教授从被走私的穿山甲中发现新冠病毒
• Identification of 2019-nCoV related coronaviruses in Malayan pangolins in southern China
• Nextstrain build for novel coronavirus (nCoV)
• 最新消息！全球首例宠物狗感染新冠病毒！难道会成为新的传播途径？
• 重磅 | 全球首次，南方科技大学等多单位合作，首次揭示新冠病毒整体结构
• Viral Architecture of SARS-CoV-2 with Post-Fusion Spike Revealed by Cryo-EM
• Nature | 陷入罗生门！穿山甲虽携带冠状病毒，但它可能不是此次新冠病毒中间宿主
• Are pangolins the intermediate host of the 2019 novel coronavirus (2019-nCoV) ?
• Mystery deepens over animal source of coronavirus
• 最新研究！龟类也可能是潜在中间宿主
• Composition and divergence of coronavirus spike proteins and host ACE2 receptors predict potential intermediate hosts of SARS‐CoV‐2
• Cell | 多国联合攻关，发现新冠病毒新的治疗靶标，同时恢复期的SARS患者的血清可阻止病毒进入细胞
• SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor
• 首次 | 中国学者开发了新冠动物模型，大大推进疫苗及药物的研发
• The Pathogenicity of SARS-CoV-2 in hACE2 Transgenic Mice
• 开通绿色通过，Cell及Science连发，亲合力高10倍以上，新冠病毒高传染性被证实，SARS相关抗体可以阻碍新冠病毒进入细胞
• Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein
• 为2019新型冠状病毒命名 |《自然-微生物学》
• The species Severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2
• 最新 | 新冠病毒被重命名 ，新冠病毒仍然被命名为SARS-CoV-2
• 重大发现 | 华中科技大学等多机构合作，首次详细报道新冠病毒对胰腺的损害，同时揭示其潜在机理
• Highly ACE2 Expression in Pancreas May Cause Pancreas Damage After SARS-CoV-2 Infection
• 最新研究：新冠病毒有2个亚型，传染力或有差异，且有人同时感染
• On the origin and continuing evolution of SARS-CoV-2
• 新冠病毒正式命名为 SARS-CoV-2，主要依据演化关系
• 中国学者发现新冠病毒149个突变点，部分患者可感染不同新冠病毒亚型
• On the origin and continuing evolution of SARS-CoV-2
• Science | 世界首次！西湖大学成功解析出新冠病毒细胞受体ACE2全长结构
• Structural basis for the recognition of the SARS-CoV-2 by full-length human ACE2
• 他们在实验室搭建“模拟市场”，再现病毒的跨物种传播过程
• Re-creating live-animal markets in the lab lets researchers see how pathogens like coronavirus jump species
• 新冠病毒可能分为两种类型，这意味着什么？
• AlphaFold抗疫，DeepMind公布六种新冠病毒蛋白质结构预测结果
• Lancet最新 | 不会引发不利的社会影响，12学者建议新冠病毒使用SARS-CoV-2
• SARS-CoV-2 is an appropriate name for the new coronavirus
• Lancet Infect Dis | 首次，兰州大学参与撰写新冠病毒感染国际诊疗规范（值得收藏）
• Guidelines for pregnant women with suspected SARS-CoV-2 infection
• 实锤 | 新冠病毒在人体内被RNA编辑的证据，人类脱氨酶对新冠病毒出手了！
• Evidence for RNA editing in the transcriptome of 2019 Novel Coronavirus
• 感染人数超SARS十倍，新冠病毒为啥这么容易人传人？
• Why does the coronavirus spread so easily between people?
• 突破 | 首次发现体内蛋白抑制新冠病毒进入机体的分子机制
• LY6E impairs coronavirus fusion and confers immune control of viral disease
• 新冠病毒为什么这么容易人传人？
• 新冠病毒免疫应答靶标预测 促进有效疫苗设计
• A sequence homology and bioinformatic approach can predict candidate targets for immune responses to SARS-CoV-2
• 中国学者称“新冠病毒演化出更强版本”，国际同行强烈反对并要求撤稿
• 新冠病毒“变异”了？专家解读《国家科学评论》相关论文
• 新冠病毒研究火热，动物模型供不应求
• Labs rush to study coronavirus in transgenic animals — some are in short supply
• The BMJ: 控制疫情需要对感染人类和兽类的冠状病毒生物学和行为有详细了解【述评】
• Coronaviruses in animals and humans
• 靶向冠状病毒抑制剂的研究进展
• 重磅 | 堪比瑞德昔韦，武汉大学及华东理工大学等多机构强力合作，发现新的强效广谱抗病毒药物，有望用于新冠肺炎治疗
• Novel and potent inhibitors targeting DHODH, a rate-limiting enzyme in de novo pyrimidine biosynthesis, are broad-spectrum antiviral against RNA viruses including newly emerged coronavirus SARS-CoV-2
• 规范野生动物保护和食品安全，预防人类感染新型病毒
• Regulating wildlife conservation and food safety to prevent human exposure to novel virus
• 荷兰两所大学科学家声称发现针对COVID-19的抗体
• 【研究】新冠病毒究竟能否通过“气溶胶”传播？美国学者如是说
• Aerosol and surface stability of HCoV-19 (SARS-CoV-2) compared to SARS-CoV-1
• 重磅 | 第四军医大学陈志南院士发现第二条新冠病毒入侵途径，对于治疗及药物开发具有重大借鉴意义
• SARS-CoV-2 invades host cells via a novel route: CD147-spike protein
• 实锤 | 秦川团队首次发现新冠病毒可以通过结膜途径传播的实验证据，警惕新的传播方式
• Evaluation of coronavirus in tears and conjunctival secretions of patients with SARS‐CoV‐2 infection
• Rhesus macaques can be effectively infected with SARS-CoV-2 via ocular conjunctival route
• 动物实验显示：新冠病毒不会发生二次感染
• Reinfection could not occur in SARS-CoV-2 infected rhesus macaques
• Nature | 新冠肺炎疫苗即将上马临床试验，复旦大学姜世勃指出安全性第一，同时谨防炒作
• Don’t rush to deploy COVID-19 vaccines and drugs without sufficient safety guarantees
• NEJM重大新发现 | 新冠病毒都成精了，在塑料表面至少生存3天以上
• 重磅 | 饶子和院士等团队首次解析了瑞德昔韦标靶的结构，对于药物开发意义重大
• Structure of RNA-dependent RNA polymerase from 2019-nCoV, a major antiviral drug target
• 新冠病毒突变了！部分检测试剂盒将失效！
• Discovery of a 382-nt deletion during the early evolution of SARS-CoV-2
• 饶子和团队解析“人民的希望”的靶点高分辨率结构
• 中国学者呼吁：不要急于部署无充分安全保证的COVID-19疫苗和药物
• 饶子和团队等成功解析新冠病毒复制机器三维结构，为药物研发铺路
• 云南大学揭示马来穿山甲可能是SARS-CoV-2类似病毒潜在自然宿主
• Probable pangolin origin of SARS-CoV-2 associated with the COVID-19 outbreak
• Cell子刊 | 突破，云南大学揭示马来穿山甲可能是SARS-CoV-2类似病毒潜在自然宿主
• Science重磅 | 首次获得新冠病毒蛋白酶结构，同时开发了抑制剂
• Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved α-ketoamide inhibitors
• Nature Biotec重磅 | 构建多组织人源化的小鼠，对于研究新冠病毒致病性，疫苗有效性，药物研发奠定基础
• Precision mouse models with expanded tropism for human pathogens
• Epidemiological Characteristics of 2143 Pediatric Patients With 2019 Coronavirus Disease in China
• Science重磅 | 祭出大杀器，德国/英国等4个国家使用具有百年历史的抗结核疫苗来预防新冠病毒感染（高风险人群）
• 为何说新冠病毒的实验室起源论是不足信的？|《自然-医学》
• The proximal origin of SARS-CoV-2
• Cell：从基因组学角度解析SARS-CoV-2的起源和出现
• A Genomic Perspective on The Origin and Emergence of SARS-CoV-2
• 李兰娟呼吁深入研究病毒载量和抗体反应：对治疗和疫苗很重要
• SARS-CoV-2: virus dynamics and host response
• Stability of SARS-CoV-2 in different environmental conditions
• 《科学》封面故事｜新冠病毒突刺蛋白结构以及ACE2受体结构
• Coronavirus: Research, Commentary, and News
• 发现穿山甲携带SARS-CoV-2近缘冠状病毒 |《自然》论文
• identifying SARS-CoV-2 related coronaviruses in Malayan pangolins
• 西湖大学「新冠」研究登上Science封面，揭秘病毒进入人体那一刻
• 新冠病毒侵染人体那一刻发生了什么？西湖大学新冠研究登上《Science》封面
• 生物学的机器学习：使用K-Means和PCA进行基因组序列分析 COVID-19接下来如何突变？
• Nature | 管轶/胡艳玲发现穿山甲可能是新冠肺炎病毒的宿主
• 中国新冠研究登上Science封面，全球首次揭示新冠病毒人体蛋白受体结构
• 重大进展 | 中国学者发现新冠病毒致病新机制：破坏诱导多能干细胞的多能性并将其转变为成纤维细胞
• The Nucleocapsid Protein of SARS-CoV-2 Abolished Pluripotency in Human Induced Pluripotent Stem Cells
• “早期案例并非都与华南海鲜市场有关，源头可能更复杂”
• 美科学家：武汉绝不是新冠病毒源头
• The proximal origin of SARS-COV-2
• 新研究发现排毒期长达49天新冠病例，或为新亚型
• A special case of COVID-19 with long duration of viral shedding for 49 days
• 罕见 | 中国学者等连续发表8篇CNS文章，系统介绍新冠病毒致病的分子机制
• Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor
• Structural basis of receptor recognition by SARS-CoV-2
• SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically-proven protease inhibitor
• Structural and functional basis of SARS-CoV-2 entry by using human ACE2
• Cell Res | 突破，复旦大学陆路/姜世勃等发现新的冠状病毒抑制剂，有望快速的应用于临床
• Inhibition of SARS-CoV-2 (previously 2019-nCoV) infection by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion
• 清华等团队从蝙蝠“百毒不侵”中找答案：发现新冠病毒抑制剂
• Orthogonal genome-wide screenings in bat cells identify MTHFD1 as a target of broad antiviral therapy
• 对40种病毒变体基因测序，冰岛发现全球首例“双重感染者”
• SARS-CoV-2病毒RNA在粪便样本中长期存在
• Prolonged presence of SARS-COV-2 viral RNA in faecal samples
• Cell & CHOM：新冠病毒的结构、功能基础以及动态免疫反应
• 清华大学：通过CRISPR文库敲除蝙蝠2万多个基因，发现多个广谱抗病毒药物靶点和抗新冠病毒潜在药物分子
• 清华大学药学院谭旭课题组从蝙蝠基因组学研究发现广谱抗病毒药物靶点和抗新冠病毒潜在药物分子
• 新发现 | 王军平/赵景宏/魏冬青发现人类防御素可抵抗新冠病毒，消化道症状少的原因被揭示
• Lectin-like Intestinal Defensin Inhibits 2019-nCoV Spike binding to ACE2
• Nature报道新冠病毒新研究：传猫易，传狗难，猫狗能否传人不明确
• Susceptibility of ferrets, cats, dogs, and different domestic animals to SARS-coronavirus-2
• Coronavirus can infect cats — dogs, not so much
• 猫能感染新冠病毒——狗不易感
• 广谱抗冠状病毒多肽有望防控疫情
• Inhibition of SARS-CoV-2 (previously 2019-nCoV) infection by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion
• Cell：不用疫苗也能预防新冠病毒！重组人ACE2蛋白可削弱新型冠状病毒的感染能力，幅度超千倍
• Inhibition of SARS-CoV-2 infections in engineered human tissues using clinical-grade soluble human ACE2
• 加快审稿 | 中国学者等连续发表9篇CNS文章，系统介绍新冠病毒致病的分子机制
• A highly conserved cryptic epitope in the receptor-binding domains of SARS-CoV-2 and SARS-CoV
• 超过10%的猫呈现阳性，石正丽/金梅林发现新冠病毒可以感染猫
• SARS-CoV-2 neutralizing serum antibodies in cats: a serological investigation
• 新研究：武汉部分与患者“密切接触”猫出现新冠感染
• “新冠病毒可能已在人类中传播数月甚至数年”
• “四院院士”谢晓亮：寻找新冠病毒中和抗体
• 颠覆认知 | 2个团队体外人工合成出新冠病毒：能在一周之内生产或改造出大量病毒活体
• An infectious cDNA clone of SARS-CoV-2
• “零号病人”的概念并不科学，这可能将我们带往错误的方向
• Patient zero: why it’s such a toxic term
• 最新计算分析：树鼩、雪貂或是潜在中间宿主
• Computational analysis suggests putative intermediate animal hosts of the SARS-CoV-2
• 大跌眼镜 | 新冠病毒再次升级，老虎都不能幸免：老虎被检测为新冠病毒阳性
• 还在重复使用口罩？《柳叶刀》报告：新冠病毒可在口罩上存活7天
• Stability of SARS-COV-2 in different environmental conditions
• 专家：有必要研究猫等宠物是否感染新冠，但不必恐慌
• Science | 重大进展，陈化兰/步志高/武桂珍发现猫能感染新冠、狗不易感，是否传人不明确
• Susceptibility of ferrets, cats, dogs, and other domesticated animals to SARS–coronavirus 2
• Cell重磅 | 颠覆先前的认知，首次系统获得新冠病毒转录组及表观转录组学数据
• The architecture of SARS-CoV-2 transcriptome
• 1天可测序及分析数百万样品 | 张锋开发新技术，可满足全球新冠肺炎的测序工作
• LAMP-Seq: Population-Scale COVID-19 Diagnostics Using a Compressed Barcode Space
• 中科院学者研发新冠病毒核酸快速检测系统 45分钟出结果 准确率达99%
• 10篇CNS成果 | 饶子和/蒋华良/杨海涛解析新冠病毒主蛋白酶三维结构，发现候选药物
• Structure of Mpro from COVID-19 virus and discovery of its inhibitors
• 科学家成功解析新冠病毒主蛋白酶三维结构
• Study charts the “incipient supernova” of COVID-19 through genetic mutations as it spread from China and Asia to Australia, Europe and North America. Researchers say their methods could be used to help identify undocumented infection sources
• Phylogenetic network analysis of SARS-CoV-2 genomes
• 突破 | 首次，徐华强/许叶春/张岩/张抒扬团队联手合作，获得了瑞德昔韦与靶标的复合物的分子细节，对于药物研究有重大推动作用
• Structural Basis for the Inhibition of the RNA-Dependent RNA Polymerase from SARS-CoV-2 by Remdesivir
• 剑桥大学最新研究：基因网络分析揭示北美、中国、欧洲的新冠病毒差异
• Nature拳头综述（IF=44）| 首次，曹雪涛系统盘点新冠病毒产生的免疫学反应及治疗方法（值得首次）
• COVID-19: immunopathology and its implications for therapy
• 再添实证 | 新冠病毒不会发生母婴垂直传播
• Vaginal Delivery Report of a Healthy Neonate Born to a Convalescent Mother with COVID­19
• 曹雪涛专访 | 新发《自然》子刊评述文章，谈新冠肺炎免疫病理和治疗启示
• 【研究】芬兰科学家论证新冠病毒可在空气中传播
• Researchers modelling the spread of the coronavirus emphasise the importance of avoiding busy indoor spaces
• 人源可溶性重组ACE2蛋白：潜在的新冠肺炎药物 | Cell Press青促会述评
• 最新 | 武汉大学李红良等系统介绍ACE2的功能及在新冠肺炎中潜在治疗作用
• ACE2 the Janus-faced protein – from cardiovascular protection to severe acute respiratory syndrome-coronavirus and COVID-19
• 疫情期间，动物进城没啥，我怕他们回去……
• ACE2是SARS-CoV-2进入细胞所需的受体
• ACE2 Is the SARS-CoV-2 Receptor Required for Cell Entry
• 一位重症医生对新冠肺炎疫情防治的思考
• Nature点评 | 蝙蝠是人类病毒的主要来源，但啮齿动物老鼠等也需要考虑
• Viral zoonotic risk is homogenous among taxonomic orders of mammalian and avian reservoir hosts
• Bats are a key source of human viruses — but they’re not special
• 蝙蝠传染流浪狗？新冠病毒溯源新假说发表，但尚无实际检测证据
• Extreme genomic CpG deficiency in SARS-CoV-2 and evasion of host antiviral defense
• Cell重磅 | 脑洞大开，首次提出CRISPR技术用来抗新冠病毒：6个靶点设计，可以靶向绝大部分冠状病毒
• Development of CRISPR as an antiviral strategy to combat SARSCoV-2 and influenza
• 病毒溯源没那么简单！历史上很多疾病来源至今是谜
• 实锤！视频显示讲话产生的液滴在密闭空间悬浮数秒
• Visualizing Speech-Generated Oral Fluid Droplets with Laser Light Scattering
• 钟南山专访 | 对近600项临床试验不要完全贬读！
• 基于CRISPR的SARS-CoV-2快速诊断技术 | 《自然-生物技术》论文
• CRISPR–Cas12-based detection of SARS-CoV-2
• Clinical benefit of remdesivir in rhesus macaques infected with SARS-CoV-2
• 细胞因子，转录组结构和免疫失调——多角度解析新冠病毒
• COVID-19: a new virus, but an old cytokine release syndrome
• 【观点】高层建筑病毒传播的风险：注意洗浴间的“反水弯”！
• CORONAVIRUS: PEOPLE IN TALL BUILDINGS MAY BE MORE AT RISK – HERE’S HOW TO STAY SAFE
• 李兰娟新发论文：找到新冠病毒19个致病性新突变！
• Patient-derived mutations impact pathogenicity of SARS-CoV-2
• Cell | 重大进展，开辟新思路，使用抗体嫁接技术，产生大量新冠病毒抗体，有重大的临床应用意义
• Structural Basis for Potent Neutralization of Betacoronaviruses by Single-domain Camelid Antibodies
• Nature Biotech | 横空出世，新冠病毒快速及便捷式检测系统被开发出：可在应急场所迅速检测
• CRISPR–Cas12-based detection of SARS-CoV-2
• 突破 | 中国学者发布全球首个新冠疫苗动物实验结果：在恒河猴模型中安全有效
• Rapid development of an inactivated vaccine for SARS-CoV-2
• 李兰娟团队新发论文：找到新冠病毒19个致病性新突变，警惕药物和疫苗研发影响
• Complex Immune Dysregulation in COVID-19 Patients with Severe Respiratory Failure
• 首次在室外空气中检测到新冠病毒，附着在空气中颗粒物上持久存在
• SARS-Cov-2 RNA Found on Particulate Matter of Bergamo in Northern Italy: First Preliminary Evidence
• Clinical Data on Hospital Environmental Hygiene Monitoring and Medical Staff Protection during the Coronavirus Disease 2019 Outbreak
• Cell | 惊人发现，ACE2是干扰素诱导基因，新冠病毒感染期间会加重病毒感染
• SARS-CoV-2 receptor ACE2 is an interferon-stimulated gene in human airway epithelial cells and is detected in specific cell subsets across tissues
• Comparative tropism, replication kinetics, and cell damage profiling of SARS-CoV-2 and SARS-CoV with implications for clinical manifestations, transmissibility, and laboratory studies of COVID-19: an observational study
• 传播病毒没有特殊物种
• Viral zoonotic risk is homogenous among taxonomic orders of mammalian and avian reservoir hosts
• 加快审稿 | 中国学者等连续发表11篇CNS文章，系统介绍新冠病毒致病的分子机制
• Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease
• 为什么“新冠病毒人造论”站不住脚？这篇文章说清楚了
• 多组织遗传学分析表明SARS-CoV-2可能感染特定鼻细胞 |《自然-医学》论文
• SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes
• 前沿 |《细胞》：新冠病毒突破人体防线的能力，真的太强了！
• 病毒检测的那些事儿
• Cell：不用疫苗也能预防新冠病毒！重组人ACE2蛋白可削弱新型冠状病毒的感染能力，幅度超千倍
• 新进展 | 高福/施一首次解析了新冠病毒聚合酶核心复合物的结构
• Structural and biochemical characterization of nsp12-nsp7-nsp8 core polymerase complex from COVID-19 virus
• Aerodynamic analysis of SARS-CoV-2 in two Wuhan hospitals
• 什么是ADE效应？——好心可能办坏事！
• Nature | 武汉大学等多单位合作发现新冠病毒可能通过气溶胶传播，执行严格的消毒措施，可限制该途径的传播
• 在气溶胶中检测到SARS-CoV-2遗传物质 |《自然》论文
• 柳叶刀-微生物 | SARS-CoV-2在不同环境中的稳定性
• Stability of SARS-COV-2 in different environmental conditions
• 《自然》关于新冠的最新发现
• 重大突破 | 复阳的原因被发现！卞修武/平轶方/刘新东首次发现新冠患者复阳的潜在机制：新冠病毒都隐藏在了肺中
• Pathological evidence for residual SARS-CoV-2 in pulmonary tissues of a ready-for-discharge patient
• 新冠肺炎研究：COVID-19与吸烟的关系：尼古丁是隐藏的关连点吗？
• COVID-19 and Smoking. Is Nicotine the Hidden Link?
• 冠状病毒是空气传播的吗？专家并不同意
• Is the coronavirus airborne? Experts can’t agree
• Nature罕见 | 百位研究人员合作，首次绘制出新冠病毒蛋白相互作用图谱，为药物开发设计奠定基础
• A SARS-CoV-2 protein interaction map reveals targets for drug repurposing
• 【观点】病毒测试准确吗？“强直觉“比”弱测试“更靠谱！
• How accurate are coronavirus tests?
• SARS-CoV-2 and Bats: From Flight to Fighting COVID-19
• Science重大进展 | 全球首次获得新冠病毒刺突蛋白的糖基化全景图谱，对于药物开发及疫苗设计具有重大推动作用
• Site-specific glycan analysis of the SARS-CoV-2 spike
• Nature | 颠覆认知， 2个团队体外人工合成出新冠病毒：能在一周之内生产或改造出大量病毒活体
• Rapid reconstruction of SARS-CoV-2 using a synthetic genomics platform
• An infectious cDNA clone of SARS-CoV-2
• Comparative ACE2 variation and primate COVID-19 risk
• Lack of Rule-Adherence During Mountain Gorilla Tourism Encounters in Bwindi Impenetrable National Park, Uganda, Places Gorillas at Risk From Human Disease
• 科学家保护类人猿免遭新冠病毒感染
• 发现SARS-CoV-2的中和抗体 |《自然-通讯》论文
• A human monoclonal antibody blocking SARS-CoV-2 infection
• 快速重建SARS-CoV-2用于研究 |《自然》论文
• “羊驼产生的抗体能消灭新冠病毒，治疗效果良好”
• Structural Basis for Potent Neutralization of Betacoronaviruses by Single-Domain Camelid Antibodies
• Hoping Llamas Will Become Coronavirus Heroes
• 中国团队发布全球首个新冠疫苗动物实验研究结果
• Rapid development of aninactivated vaccine for SARS-CoV-2
• 中国团队发布全球首个新冠疫苗动物实验研究结果，安全有效
• Nature首次 | 再取新突破，秦川团队开发了新冠动物模型，大大推进疫苗及药物的研发
• The pathogenicity of SARS-CoV-2 in hACE2 transgenic mice
• Nature重磅 | 新冠病毒的起源被解密，华南农业大学等多团队合作：发现新冠病毒可能是穿山甲冠状病毒与蝙蝠冠状病毒重组产生
• Isolation of SARS-CoV-2-related coronavirus from Malayan pangolins
• Science：中国团队发布首个新冠疫苗动物实验研究结果，在恒河猴模型中安全有效
• Nature重磅 | 中国团队：新冠病毒或为蝙蝠穿山甲冠状病毒重组
• 晶体结构揭示SARS-CoV-2的药物靶点及其抑制剂之间的互作 |《自然-结构和分子生物学》论文
• Structural basis for the inhibition of SARS-CoV-2 main protease by antineoplastic drug carmofur
• Nature | 华南农大研究表明，新冠病毒由穿山甲冠状病毒和蝙蝠冠状病毒重组而来
• 高福院士最新论文！从康复患者体内发现2种抗体，可阻断新冠病毒与ACE2结合，为疫苗设计提供结构基础
• A non-competing pair of human neutralizing antibodies block COVID-19 virus binding to its receptor ACE2
• 比利时研究团队发现：羊驼可产生新冠抗体！‘草泥马’拯救人类？
• 【在线速递】武汉两所医院的SARS-CoV-2空气动力学分析
• A human monoclonal antibody blocking SARS-CoV-2 infection
• 重大进展 | 连发3篇Nature/Science，秦川等团队开发了新冠灵长类动物模型，大大推进疫苗及药物的研发
• Respiratory disease in rhesus macaques inoculated with SARS-CoV-2
• Comparative pathogenesis of COVID-19, MERS, and SARS in a nonhuman primate model
• Cell重磅 | 深圳市第三人民医院张政等团队开发新方法，可以鉴定新冠病毒感染人类精确的细胞类型及组织
• Host-viral infection maps reveal signatures of severe COVID-19 patients
• 一种检测SARS-CoV-2抗体的方法 |《自然-医学》论文
• A serological assay to detect SARS-CoV-2 seroconversion in humans
• Comparative tropism, replication kinetics, and cell damage profiling of SARS-CoV-2 and SARS-CoV with implications for clinical manifestations, transmissibility, and laboratory studies of COVID-19: an observational study
• Science最新 | 高福院士等从康复患者体内发现2种抗体，可阻断新冠病毒与ACE2结合，为疫苗设计提供结构基础
• A noncompeting pair of human neutralizing antibodies block COVID-19 virus binding to its receptor ACE2
• COVID-19 outcomes and the human genome
• SARS-CoV-2能够感染肠细胞 |《自然-医学》论文
• Infection of bat and human intestinal organoids by SARS-CoV-2
• 柳叶刀-微生物 | SARS-CoV-2的细胞趋向性
• SARS-CoV-2 cellular tropism
• 新冠康复者体内产生抗体因人而异 | Cell Press 对话科学家
• Detection of SARS-CoV-2-specific humoral and cellular immunity in COVID-19 convalescent individuals
• 这名未上过大学的女科学家，让冠状病毒首次“显出原形”
• Nature 3连发 | 重磅，中国多机构合作，发现人可以将新冠病毒传染给狗，但是狗传染人未知
• Infection of dogs with SARS-CoV-2
• Pathogenesis and transmission of SARS-CoV-2 in golden hamsters
• Dogs caught coronavirus from their owners, genetic analysis suggests
• 新冠病毒可以人传狗？（但未发现狗传人）
• NEJM | 实锤！受感染的猫可以在猫群之间进行传播新冠病毒，猫可能是SARS-CoV-2的沉默中间宿主
• Transmission of SARS-CoV-2 in Domestic Cats
• Nature Medicine | 突破，袁国勇团队首次得到了新冠病毒可以感染蝙蝠的直接证据
• Structure of the RNA-dependent RNA polymerase from COVID-19 virus
• 高福院士发表Science论文！从康复患者体内发现2种抗体，可阻断新冠病毒与ACE2结合，为疫苗设计提供结构基础
• NEJM 发现新冠病毒“猫传猫”，WHO 建议与宠物保持一定“隔离”
• SARS-Coronavirus (CoV)-2 and cats
• Cats can infect other cats with virus that causes COVID-19
• 史卫峰团队为新冠病毒“自然起源”再添有力证据 | CellPress对话科学家
• A novel bat coronavirus closely related to SARS-CoV-2 contains natural insertions at the S1/S2 cleavage site of the spike protein
• A highly conserved cryptic epitope in the receptor binding domains of SARS-CoV-2 and SARS-CoV
• Tracing back roots: unravelling feline enteric coronavirus pathogenesis to combat feline infectious peritonitis
• Proteomics of SARS-CoV-2-infected host cells reveals therapy targets
• 突破 | 中国科学家公布实验室首个mRNA新冠候选疫苗的动物数据
• A single dose SARS-CoV-2 simulating particle vaccine induces potent neutralizing activities
• Attenuated SARS-CoV-2 variants with deletions at the S1/S2 junction
• Nature | 重大进展，陈赛娟/卢洪洲等发现新冠病毒的变异，并不会显著影响患者临床结果
• Viral and host factors related to the clinical outcome of COVID-19
• 突破 | 连发5篇Nature/Science，中国等学者发现恒河猴感染新冠病毒，可对于再次暴露新冠病毒具有保护作用
• SARS-CoV-2 infection protects against rechallenge in rhesus macaques
• DNA vaccine protection against SARS-CoV-2 in rhesus macaques
• 中国学者鉴定出可阻止新冠病毒入侵的中和抗体
• 新冠病毒能够感染肠细胞
• 再添力证！石正丽重磅新论文：病毒来自自然，进一步证实蝙蝠SARS样冠状病毒跨物种感染
• Evolutionary arms race between virus and host drives genetic diversity in bat SARS related coronavirus spike genes
• 突破 | 连发Cell及Nature，石正丽团队及秦川团队同时开发出新冠动物模型
• Pathogenesis of SARS-CoV-2 in transgenic mice expressing human angiotensin-converting enzyme 2
• 生物化学 | 消灭新型冠状病毒，可能有新策略？
• 从细胞生物学的角度看COVID-19的发病机制
• Pathogenesis of COVID-19 from a cell biology perspective
• 谢晓亮团队：利用单细胞测序技术筛选新冠有效抗体 | CellPress对话科学家
• 振奋人心的进展 | 3篇Nature/Cell，高福，张政及秦川等�������������队发现新冠特异性的中和抗体，可阻止新冠病毒的感染
• A human neutralizing antibody targets the receptor binding site of SARS-CoV-2
• Cell | 使用新方法，发现鼻是新冠病毒感染的门户及新冠病毒呈现梯度感染模式
• SARS-CoV-2 Reverse Genetics Reveals a Variable Infection Gradient in the Respiratory Tract
• 动态 | 研究院与人民卫生出版社联合制作的新型冠状病毒检测方法培训视频正式发布
• 专家警告：可能会出现新冠病毒和MERS病毒的嵌合病毒
• 意大利科学界证实：新冠病毒毒性正在减弱，新感染者几乎无症状！
• 饶子和、王权、龚鹏团队：新冠病毒聚合酶催化机制 | CellPress对话科学家
• Structural basis for RNA replication by the SARS-CoV-2 polymerase
• Cell突破 | 温州医科大学与西湖大学强力合作，揭示了新冠标志物的特征
• Proteomic and Metabolomic Characterization of COVID-19 Patient Sera
• Cell：西湖大学再获重要突破，郭天南等发现新冠重症患者生物标志物
• 百万年进化，上百种病毒！数据揭秘你可能并不了解的蝙蝠
• 动物传播新冠病毒的风险有几分？
• What’s the risk that animals will spread the coronavirus?
• 科学家发现抗新冠全人源纳米抗体
• Identification of Human Single-Domain Antibodies against SARS-CoV-2
• 冠状病毒疫苗已经用了80年，有了它才有便宜的炸鸡和炒蛋
• 4篇Cell等连发 | 高福与秦川等团队联手合作，首次开发灭活的新冠病毒疫苗，动物试验有效：对新冠病毒的感染有保护作用
• Development of an inactivated vaccine candidate, BBIBP-CorV, with potent protection against SARS-CoV-2
• Virological assessment of hospitalized patients with COVID-2019
• 高福、秦川团队：灭活候选疫苗BBIBP-CorV可提供对抗SARS-CoV-2的强大保护作用
• 重大进展 | 连发4篇Cell及Nature，赵金存团队，石正丽团队及秦川团队等开发出新冠小鼠动物模型
• Generation of a Broadly Useful Model for COVID-19 Pathogenesis Vaccination, and Treatment
• A SARS-CoV-2 infection model in mice demonstrates protection by neutralizing antibodies
• 柳叶刀-呼吸病学 | 通风不良的空间中的小飞沫气溶胶与SARS-CoV-2传播
• Small droplet aerosols in poorly ventilated spaces and SARS-COV-2 transmission
• SARS-CoV-2的PCR检测法：对检测法进行检测
• PCR Assays for SARS-CoV-2: Testing the Tests
• 进入SARS-CoV-2抗体检测的时代：问题比答案还多
• Entering the Era of SARS-CoV-2 Antibody Testing: More Questions than Answers
• 对COVID-19主要蛋白酶的分子模拟研究
• Identification of potential binders of the main protease 3CLpro of the COVID-19 via structure-based ligand design and molecular modeling
• SARS-CoV-2 Reverse Genetics Reveals a Variable Infection Gradient in the Respiratory Tract
• 破天荒 | 8篇CNS连发，高福，张政及秦川等团队发现新冠特异性的中和抗体，可阻止新冠病毒的感染
• Antibody cocktail to SARS-CoV-2 spike protein prevents rapid mutational escape seen with individual antibodies
• Isolation of potent SARS-CoV-2 neutralizing antibodies and protection from disease in a small animal model
• Potent neutralizing antibodies from COVID-19 patients define multiple targets of vulnerability
• Studies in humanized mice and convalescent humans yield a SARS-CoV-2 antibody cocktail
• Broad neutralization of SARS-related viruses by human monoclonal antibodies
• 新冠检测大显身手的质谱法，应用前景十分广阔
• Progress in Pathogen Identification Based on Mass Spectrometry
• 钟南山指导团队构建首个新冠肺炎非转基因鼠模型
• A SARS-CoV-2 Infection Model in Mice Demonstrates Protection by Neutralizing Antibodies
• Generation of a Broadly Useful Model for COVID-19 Pathogenesis, Vaccination, and Treatment
• 赵金存团队：针对COVID-19发病机制、疫苗研发及治疗的新小鼠模型 | CellPress对话科学家
• Generation of a Broadly Useful Model for COVID-19 Pathogenesis Vaccination, and Treatment
• 实锤 | 新冠病毒在人体内被RNA编辑的证据，人类脱氨酶对新冠病毒出手了！
• Evidence for host-dependent RNA editing in the transcriptome of SARS-CoV-2
• Bat-borne virus diversity, spillover and emergence
• Known SARS‐CoV ‐2 infections: The tip of an important iceberg
• Science突破 | 西湖大学等多机构合作，陈薇/周强/李建民发现新的新冠中和抗体
• A neutralizing human antibody binds to the N-terminal domain of the Spike protein of SARS-CoV-2
• 5篇Cell等连发 | 海南医学院，中科院等多单位合作，高福与秦川等团队开发出通用的冠状病毒疫苗设计方法
• Development of an Inactivated Vaccine Candidate, BBIBP-CorV, with Potent Protection against SARS-CoV-2
• A universal design of betacoronavirus vaccines against COVID-19, MERS and SARS
• Cell：针对所有β冠状病毒，高福院士等开发出通用疫苗策略
• Cell重磅：不止防新冠！高福团队开发出防SARS、MERS等β属冠状病毒通用疫苗设计！
• 最新：陈薇院士团队开发的重组新冠疫苗已获批军队内部使用！
• SARS-CoV-2抗体的共同表位和复发特征 | CellPress论文速递
• Structures of human antibodies bound to SARS-CoV-2 spike reveal common epitopes and recurrent features of antibodies
• DNA疫苗在猴体内产生对抗SARS-CoV-2感染的防护作用
• DNA Vaccine Protects Against SARS-CoV-2 Infection in Monkeys
• 新冠病毒两大分支揭示重要疫源地和重症化信息
• A race to determine what drives COVID-19 severity
• Cell Res | 连续取得突破，有望加快疫苗研究，袁国勇团队发现了新冠病毒刺突蛋白的免疫作用表位
• Mining of epitopes on spike protein of SARS-CoV-2 from COVID-19 patients
• 连续发表6篇CNS | 秦川团队首次发现感染新冠病毒一次，可防止再次感染
• Primary exposure to SARS-CoV-2 protects against reinfection in rhesus macaques
• Cell重磅 | 全球新冠病毒正发生突变，传染性增加近10倍，疫苗开发将成为挑战
• Tracking changes in SARS-CoV-2 Spike: evidence that D614G increases infectivity of the COVID-19 virus
• 从细胞因子风暴的角度理解COVID-19 | CellPress论文速递
• Cytokine Storms: Understanding COVID-19
• 一种针对所有β冠状病毒的疫苗通用设计，可用于预防COVID-19、MERS 和SARS | CellPress论文速递
• 重大突破 | 石正丽/单超/袁志明生成了非人类灵长类动物新冠模型
• Infection with novel coronavirus (SARS-CoV-2) causes pneumonia in Rhesus macaques
• D614G变异增强了COVID-19病毒的传染性丨CellPress论文速递
• 知己知彼才好战胜疫情：如何让病毒课嗨起来 | Virology Journal
• Virus goes viral: an educational kit for virology classes
• 冠状病毒结构提示SARS-CoV-2演化 |《自然-结构和分子生物学》论文
• SARS-CoV-2 and bat RaTG13 spike glycoprotein structures inform on virus evolution and furin-cleavage effects
• 尚无证据表明新冠病毒增进了人际传播：著名病毒学教授如是说
• No evidence for increased human transmission of SARS-CoV-2
• SARS-CoV-2 in fruit bats, ferrets, pigs, and chickens: an experimental transmission study
• 大羊驼来源抗体能中和SARS-CoV-2 |《自然-结构和分子生物学》论文
• Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2
• 新冠病毒可气溶胶传播？尚无强有力证据但各国政府已开始行动
• Mounting evidence suggests coronavirus is airborne — but health advice has not caught up
• 【研究】麦肯锡：气溶胶有传播病毒风险，空调系统需要升级改造！
• Can HVAC systems help prevent transmission of COVID-19?
• Cell突破 | 王佑春/黄维金团队首次发现刺突蛋白突变会对中和抗体产生抗性
• The impact of mutations in SARS-CoV-2 spike on viral infectivity and antigenicity
• Nature意外发现！非感染者体内竟存在SARS-CoV-2抗体！
• SARS-CoV-2-specific T cell immunity in cases of COVID-19 and SARS， and uninfected controls
• 最新研究首次证实：新冠病毒不会通过蚊子传播，特别是对人类的传播
• Explained: How we know mosquitoes cannot spread coronavirus
• 【观点】世卫组织表态： “不能排除” 新冠病毒空气传播途径！
• The debate over “airborne” coronavirus spread, explained
• Cross-neutralization of SARS-CoV-2 by a human monoclonal SARS-CoV antibody
• NC：解析SARS-CoV spike（S）糖蛋白的融膜后结构，阐释冠状病毒的融膜机制
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• Nature | 突破！柯尊龙等人首次获得新冠完整病毒体上刺突蛋白的结构和分布
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• Can you catch COVID-19 from your neighbor’s toilet?
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• 居家防新冠，你家的地漏检查了吗？｜Science新冠专题
• Can you catch COVID-19 from your neighbor’s toilet?
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• Linear epitopes of SARS-CoV-2 spike protein elicit neutralizingantibodies in COVID-19 patients
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• COVID-19 makes B cells forget, but T cells remember
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• Molecular architecture of the SARS-CoV-2 virus
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• Cell：揭开庐山真面目，李兰娟/李赛首次解析新冠病毒完整分子结构
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• Cell：揭示T细胞在控制SARS-CoV-2和降低COVID-19严重程度方面发挥着主导作用
• Antigen-specific adaptive immunity to SARS-CoV-2 in acute COVID-19 and associations with age and disease severity
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• Probable Evidence of Fecal Aerosol Transmission of SARS-CoV-2 in a High-Rise Building
• Nature再发神文 | 神奇的研究！灭亡了数万年的尼安德特人，决定了新冠肺炎患者的临床严重程度
• The major genetic risk factor for severe COVID-19 is inherited from Neanderthals
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• Nature重磅：中国人很安全，新冠重症风险遗传自灭绝的尼安德特人，印度和欧洲人风险高
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• High-resolution structures of the SARS-CoV-2 2′-Omethyltransferase reveal strategies for structure-based inhibitor design
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• Effectiveness of 222-nm ultraviolet light on disinfecting SARS-CoV-2 surface contamination
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• Characteristics of SARS-CoV-2 and COVID-19
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• Furin, a potential therapeutic target for COVID-19
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• Science重磅 | 病毒感染通用机制：这一蛋白分子有望同时抑制埃博拉和新冠病毒
• InhibitingEbola virus and SARS-CoV-2 entry
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• Japan researchers show masks do block coronavirus, but not perfectly
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• Seeding of outbreaks of COVID-19 by contaminated fresh and frozen food
• Cell：重大进展！包括新冠病毒在内的β冠状病毒利用溶酶体劫持和离开受感染细胞
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• Nature：通过构建肺部类器官和结肠类器官鉴定出新冠病毒抑制剂
• Identification of SARS-CoV-2 Inhibitors using Lung and Colonic Organoids
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• β-Coronaviruses use lysosomes for egress instead of the biosynthetic secretory pathway
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• Science：美洲驼纳米抗体有望成为对抗新冠病毒的强大武器
• Versatile and multivalent nanobodies efficiently neutralize SARS-CoV-2
• Llama nanobodies could be a powerful weapon against COVID-19
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• opvCRISPR: One-pot visual RT-LAMP-CRISPR platform for SARS-cov-2 detection
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• Infection of Human Sweat Glands by SARS-CoV-2
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• Engineered trimeric ACE2 binds viral spike protein and locks it in “Three-up” conformation to potently inhibit SARS-CoV-2 infection
• bioRxiv：新冠病毒突变N439K竟能削弱中和抗体的活性
• The circulating SARS-CoV-2 spike variant N439K maintains fitness while evading antibody-mediated immunity
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• Addendum: A pneumonia outbreak associated with a new coronavirus of probable bat origin
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• Nat Med：新冠病毒感染康复阶段的免疫记忆如何形成的？
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• Nature：在日本和柬埔寨发现与新冠病毒密切相关的冠状病毒
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• Can dogs smell COVID? Here’s what the science says
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• Science新冠合集｜荷兰水貂养殖场发生SARS-CoV-2双向传播
• Transmission of SARS-CoV-2 on mink farms between humans and mink and back to humans
• 鼻拭子+手机显微镜！新冠低成本快速即时筛查 | Cell Press 新冠中心论文速递
• Amplification-free detection of SARS-CoV-2 with CRISPR-Cas13a and mobile phone microscopy
• 新冠康复者体内现罕见真菌，死亡率50%
• ​南非、英国现病毒新变种 新冠病毒变异会影响疫苗有效性吗？
• 太可怕：新冠病毒新突变，毒株亲和力提高1000倍，传播提高70%！已经成为伦敦地区主要毒株
• 新冠、人、动物
• Science新冠合集｜SARS-CoV-2刺突蛋白突变对病毒传播及致病性的影响
• SARS-CoV-2 D614G variant exhibits efficient replication ex vivo and transmission in vivo
• 高福院士团队在新冠病毒对蝙蝠ACE2跨种识别机制研究中取得进展
• Cross-species recognition of SARS-CoV-2 to bat ACE2
• 全基因组筛查冠状病毒宿主因子网络 | Cell Press新冠中心论文速递
• Genome-scale identification of SARS-CoV-2 and pan-coronavirus host factor networks
• The BMJ | 来自社区试点的研究结果显示，侧向层析检测设备对新冠肺炎检测不可靠
• Covid-19: Safety of lateral flow tests questioned after they are found to miss half of cases
• 新冠病毒中和抗体保护患者免遭再感染 | Cell Press 新冠中心论文速递
• COVID-19 neutralizing antibodies predict disease severity and survival
• 针对新冠病毒B.1.1.7突变毒株，第一篇专业论文上传；明确了诸多最令人关心的问题，给出处理建议
• Estimated transmissibility and severity of novel SARS-CoV-2 Variant of Concern 202012/01 in England
• STTT：新冠病毒M蛋白抑制I和III型干扰素激活，实现免疫逃逸
• T细胞记忆带你认识新冠肺炎 | Cell Press新冠中心论文速递
• T Cell Memory: Understanding COVID-19
• Science新冠｜探究SARS-CoV-2的IgA抗体的早期有效反应
• IgA dominates the early neutralizing antibody response to SARS-CoV-2
• 新冠病毒研究迎来重大进展！最新发现新冠疫苗或不引发ADE效应
• The functions of SARS-CoV-2 neutralizing and infection-enhancing antibodies in vitro and in mice and nonhuman primates
• Nature子刊 | 新冠病毒逃逸人类抗病毒免疫重要机制被揭示！
• Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) membrane (M) protein inhibits type I and III interferon production by targeting RIG-I/MDA-5 signaling
• 重磅 | 新冠病毒进入人体细胞的新型受体被发现！西湖大学及复旦大学联手合作，其在临床上有重大潜在应用
• AXL is a candidate receptor for SARS-CoV-2 that promotes infection of pulmonary and bronchial epithelial cells
• 石正丽Science发文：新冠病毒传播途径概述
• SARS-CoV-2 spillover events
• 【存照】新冠病毒传播实例：一次18小时的飞行，4位乘客舱内感染
• One 18-Hour Flight, Four Coronavirus Infections
• Cell报道丨西湖大学郭天南等首次揭示新冠患者蛋白质分子病理全景图
• Multi-organ Proteomic Landscape of COVID-19 Autopsies
• 就为这两新冠病毒变种，全球实验室拼了
• Neutralization of N501Y mutant SARS-CoV-2 by BNT162b2 vaccine-elicited sera
• Cell | 2021年首秀！西湖大学郭天南等首次揭示新冠患者蛋白质分子病理全景图
• Cell重磅：西湖大学与华科大联合研究，首次揭示新冠患者蛋白质分子病理全景图
• 以Crisp(r)基因编辑技术的视角看新冠病毒生物学 | Cell Press新冠中心论文速递
• A Crisp(r) New Perspective on SARS-CoV-2 Biology
• Nat Comm解析人体中和抗体抑制新冠病毒的分子机制
• Antibody neutralization of SARS-CoV-2 through ACE2 receptor mimicry
• 新冠病毒变异会让疫苗效力下降吗？
• Could new COVID variants undermine vaccines? Labs scramble to find out
• 俄罗斯18种病毒变异后，研究发现mRNA新冠核酸疫苗有效！
• Neutralization of N501Y mutant SARS-CoV-2 by BNT162b2 vaccine-elicited sera
• Science新冠｜两剂新冠疫苗接种间隔过长，是否会激发病毒耐药性？
• Could too much time between doses drive the coronavirus to outwit vaccines?
• 这个课程有意思：新冠如何在校园传播？UT学生计算机模拟教学楼内病毒传播过程
• 为了防止牙医被传染新冠，给患者佩戴的隔离头盔诞生了 | Physics of Fluids
• Disposable helmet retains cough droplets, minimizes transmission to dentists
• ​详述新冠｜突变是病毒的“天性”，这会成为疫苗“克星”吗？
• 武汉病毒所等联合提出电化学氧化灭活新冠病毒新途径
• Inactivating SARS-CoV-2 by electrochemical oxidation
• 我所提出电化学氧化灭活新冠病毒新途径
• 国家生物信息中心发布更新版新型冠状病毒信息库2019nCoVR
• The Global Landscape of SARS-CoV-2 Genomes, Variants, and Haplotypes in 2019nCoVR
• 火力全开！Nature Medicine再论新冠病毒起源
• On the origins of SARS-CoV-2
• 系统盘点 | 2020年曹雪涛团队发表了6篇研究成果/综述，在免疫学领域取得重大进展
• 人体如何“记住”新冠病毒 |《自然》论文
• Evolution of antibody immunity to SARS-CoV-2
• 我们研究了19位新冠患者的7种器官中的144个尸检样品，结果发现！| Cell Press对话科学家
• Multi-organ Proteomic Landscape of COVID-19 Autopsies
• 防范病毒，不要迷信两米社交距离原则
• Host-to-host airborne transmission as a multiphase flow problem for science-based social distance guidelines
• 半年！感染新冠，免疫系统“记仇”
• 赵金存教授团队首次解析SARS-CoV-2感染小鼠T细胞应答，为新型新冠疫苗研发奠定基础
• Mapping and role of T cell response in SARS-CoV-2–infected mice
• Protein & Cell：姜世勃团队总结通用冠状病毒融合抑制剂
• Pan-coronavirus fusion inhibitors as the hope for today and tomorrow
• RNA疫苗如何在新冠疫情中弯道超车？
• How COVID unlocked the power of RNA vaccines
• 上海新增3例本土确诊，中风险地区+1
• 国际合作！最新新冠病毒高清科普影像重磅来袭！
• 新冠变异病毒能逃逸免疫反应，专家纷纷表示担忧
• Fast-spreading COVID variant can elude immune responses
• 曾木圣/赵金存/柯昌文团队开发基于新冠病毒刺突蛋白受体结合域的自组装纳米颗粒蛋白候选疫苗
• Rapid Development of SARS-CoV‑2 Spike Protein Receptor-Binding Domain Self-Assembled Nanoparticle Vaccine Candidates
• 新冠病毒适应性免疫，对疫苗研发有何启示？ | Cell Press 新冠中心论文速递
• Adaptive immunity to SARS-CoV-2 and COVID-19: Cell
• “恶魔”曝光！新冠病毒真实3D图像问世
• 关于新冠病毒变种，目前所知的与未知的
• 南非出现的新冠变异株可能影响疫苗效果，我们应该如何应对？
• Cell子刊 | 尹航课题组发文揭示新冠病毒核衣壳蛋白相分离机制
• SARS-CoV-2 nucleocapsid protein undergoes liquid–liquid phase separation into stress granules through its N-terminal intrinsically disordered region
• 默克集团宣布两种新冠疫苗研发失败！
• 3D影像来了！新冠病毒原来长这样
• 清华团队曝光「新冠病毒」3D高清结构照！这个恶魔已感染1亿地球人
• 蝙蝠为何是病毒集聚地，答案可能在肠道
• Gut microbiota in antiviral strategy from bats to humans: a missing link in COVID-19
• Cell Res | 新发现！秦成峰/伊成器首次系统分析新冠病毒的m6A修饰
• The m6A methylome of SARS-CoV-2 in host cells
• 相似度达92.6%！柬埔寨在11年前的蝙蝠样本中发现毒株，与新冠高度匹配
• A novel SARS-CoV-2 related coronavirus in bats from Cambodia
• 通过逆转录多重置换扩增标记生物纳米传感器对COVID-19的高灵敏度和特异性诊断
• Highly sensitive and specific diagnosis of COVID-19 by reverse transcription multiple cross-displacement amplification-labelled nanoparticles biosensor
• 相似度达92.6%！柬埔寨在11年前的蝙蝠样本中发现毒株，与新冠高度匹配
• 王林发Nature:人类可向蝙蝠学习健康之道-衰老、癌症和抗病毒
• 清华团队曝光新冠病毒3D高清结构照！这个恶魔已感染1亿地球人
• Science：病毒序列可以揭示SARS-CoV-2如何传播和进化​
• Insights from SARS-CoV-2 sequences
• 物体表面的新冠病毒到底传不传人？
• COVID-19 rarely spreads through surfaces. So why are we still deep cleaning?
• 瑞德西韦代谢物GS-441524在小鼠模型中有效抑制SARS-CoV-2感染
• Remdesivir Metabolite GS-441524 Effectively Inhibits SARS-CoV-2 Infection in Mouse Models
• Cell Host & Microbe | 新冠病毒Nsp1缺失突变株及其分子病毒、分子流行病和
• Genomic monitoring of SARS-CoV-2 uncovers an Nsp1 deletion variant that modulates type I interferon response
• NEJM论文：新冠患者病毒核酸阳性时间远长于传染性
• Duration of Culturable SARS-CoV-2 in Hospitalized Patients with Covid-19
• Lancet Voice | SARS-CoV-2突变背后的故事
• 新冠变体D614G的研究进展综述！
• Making sense of spike D614G in SARS-CoV-2 transmission
• 评论：新冠病毒与弗林蛋白酶
• 新冠病毒在单个病人体内的演化 |《自然》论文
• SARS-CoV-2 evolution during treatment of chronic infection
• Nature | 新冠病毒在病人体内发生进化
• SARS-CoV-2刺突蛋白中发现了可驱动抗体逃逸的反复缺失｜Science新冠专题
• Recurrent deletions in the SARS-CoV-2 spike glycoprotein drive antibody escape
• Nat Med | 史佩勇团队报道RNA疫苗有效保护英国和南非变种新冠病毒感染
• Neutralization of SARS-CoV-2 spike 69/70 deletion, E484K and N501Y variants by BNT162b2 vaccine-elicited sera
• 对SARS-CoV-2具有免疫力的最佳指标
• What Is the Optimal Way to Measure Immunity to SARS-CoV-2?
• Cell突破 | 清华大学张强锋/王健伟/丁强揭示新冠病毒RNA基因组的体内结构，为治疗新冠肺炎提供新的思路
• In vivo structural characterization of the SARS-CoV-2 RNA genome identifies host proteins vulnerable to repurposed drugs
• 东南亚蝙蝠和穿山甲体内发现SARS-CoV-2相关冠状病毒的证据 |《自然-通讯》论文
• Evidence for SARS-CoV-2 related coronaviruses circulating in bats and pangolins in Southeast Asia
• Nature子刊：王林发团队在泰国的蝙蝠和穿山甲内发现SARS-CoV-2相关冠状病毒
• Increased Resistance of SARS-CoV-2 Variants B.1.351 and B.1.1.7 to Antibody Neutralization
• mRNA疫苗对SARS-CoV-2变异株效力稍降 |《自然》论文
• mRNA vaccine-elicited antibodies to SARS-CoV-2 and circulating variants
• Nature丨mRNA疫苗对新冠变异株效力下降1-3倍
• 病毒突变株究竟是怎么来的？Nature最新研究揭示了答案
• Lack of viable severe acute respiratory coronavirus virus 2 (SARS-CoV-2) among PCR-positive air samples from hospital rooms and community isolation facilities
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• 国际科学家研发药物可防病毒在雪貂中传播，日后用于人类
• Intranasal fusion inhibitory lipopeptide prevents direct-contact SARS-CoV-2 transmission in ferrets
• 英美变异新冠病毒首现合体！易传播且有抗药性！
• 备受争议！英国全球首个新冠病毒“人体挑战试验”已获道德认可
• Local Transmission of SARS-CoV-2 Lineage B.1.1.7, Brazil, December 2020
• 病毒学家: 新冠病毒的祖先在变异感染人类之前, 已潜伏在动物体内数百万年
• 新冠肺炎单细胞研究中国联盟提供新冠免疫新认识 | Cell Press新冠中心论文速递
• COVID-19 immune features revealed by a large-scale single cell transcriptome atlas
• Science | 四川大学等多单位合作，杨胜勇/雷剑及/郑永勇发现了潜在的抗新冠病毒的化合物
• SARS-CoV-2 Mpro inhibitors with antiviral activity in a transgenic mouse model
• 病毒快速检测和分析：探究基于石墨烯场效应的晶体管生物传感器的应用
• Carbon nanomaterials to combat virus: A perspective in view of COVID-19
• Nature子刊 | 新发现！中山大学联合哥伦比亚大学团队绘制新冠病毒感染免疫反应肽全图谱，可用于新冠肺炎血清学筛查诊断
• Immunoreactive peptide maps of SARS-CoV-2
• Thapsigargin Is a Broad-Spectrum Inhibitor of Major Human Respiratory Viruses: Coronavirus, Respiratory Syncytial Virus and Influenza A Virus
• 面对病毒变异，是时候让杀伤性T细胞上场了
• How ‘killer’ T cells could boost COVID immunity in face of new variants
• 抗疫新招：在雪貂中抑制病毒传播的肽，有望发展为鼻喷剂或吸入式融合抑制剂｜Science新冠专题
• 多国拉响警报！日本发现一种新型变异新冠病毒，美国已衍生出7种变异毒株
• Japan finds new COVID-19 strain, while immigration centre reports infections
• COVID-19 ‘mutation of concern’ detected in Cebu City
• Exclusive: Two variants have merged into heavily mutated coronavirus
• 7 Virus Variants Found in U.S. Carrying the Same Mutation
• Cell论文解读！抗体的效应功是有效治疗新冠肺炎的关键
• Human neutralizing antibodies against SARS-CoV-2 require intact Fc effector functions for optimal therapeutic protection
• Antibody-based COVID-19 treatments work best in concert with immune cells
• Science首次确定新冠疫苗作用效力，结果惊人！
• Immunological memory to SARS-CoV-2 assessed for up to 8 months after infection
• Science论文解读！通过鼻腔喷雾给送脂肽有望预防新冠病毒感染
• 华西医学院Science：新型冠状病毒小分子抑制剂研究论文
• 牛年红 | 中国学者连发4篇Cell，南华大学等单位首次发现部分新冠病毒变体对单克隆抗体具有耐受性
• No higher infectivity but immune escape of SARS-CoV-2 501Y.V2 variants
• A trans-complementation system for SARS-CoV-2 recapitulates authentic viral replication without virulence
• Evidence of escape of SARS-CoV-2 variant B.1.351 from natural and vaccine induced sera
• RNA polymerase III is required for the repair of DNA double-strand breaks by homologous recombination
• 牛年红 | 中国学者连发4篇Cell，南华大学等单位首次发现部分新冠病毒变体对单克隆抗体具有耐受性
• 新冠病毒比SARS病毒更耐热抗寒！且与人类受体亲和力更高！
• Comparison of the binding characteristics of SARS-CoV and SARS-CoV-2 RBDs to ACE2 at different temperatures by MD simulations
• Will the emergent SARS‐CoV2 B.1.1.7 lineage affect molecular diagnosis of COVID‐19?
• Cell | 史佩勇课题组报道一种安全高效的用于新冠病毒药物筛选和疫苗评估的新手段
• A trans-complementation system for SARS-CoV-2 recapitulates authentic viral replication without virulence
• 《自然》：两款mRNA疫苗对新冠病毒变异株效力稍降
• ​2020诺奖得主助力新冠研究，CRISPR技术揭示冠状病毒共同弱点！
• Functional interrogation of a SARS-CoV-2 host protein interactome identifies unique and shared coronavirus host factors
• 反常！美国一名婴儿体内检测出新的变异毒株，病毒载量超其他患者51000倍
• A Baby Sick With COVID-19 in Washington Had 51,000 Times More Viral Particles
• Med述评：新冠病毒中和抗体在患者感染6个月后仍稳定存在 | Cell Press论文速递
• Stable neutralizing antibody levels 6 months after mild and severe COVID-19 episodes
• Cell/Nature/Lancet | 连续取得突破！袁国勇等团队首次发现可溶性ACE2介导的SARS-CoV-2细胞进入
• Soluble ACE2-mediated cell entry of SARS-CoV-2 via interaction with proteins related to the renin-angiotensin system
• Science新冠专题｜一种可对抗多种类似SARS病毒的工程化抗体
• Broad and potent activity against SARS-like viruses by an engineered human monoclonal antibody
• 感染数月后B细胞仍可对抗SARS-CoV-2，但衍生抗体无法识别巴西和南非突变变体｜Science新冠专题
• Prolonged evolution of the human B cell response to SARS-CoV-2 infection
• 多能干细胞和类器官在新冠中的应用
• PNAS | 丁强/张荣/袁正宏团队揭示了新冠病毒广泛的潜在宿主范围
• Functional and genetic analysis of viral receptor ACE2 orthologs reveals a broad potential host range of SARS-CoV-2
• 现有疫苗全部无效！尼日利亚变种病毒成迄今最恐怖突变？
• Nature子刊 | 百年老药苏拉明可有效抑制新冠病毒，徐华强/张抒扬/余学奎/张磊砢合作解析新冠病毒复制酶与苏拉明复合物结构
• Structural basis for inhibition of the SARS-CoV-2 RNA polymerase by suramin
• Nature子刊 | 百年老药苏拉明可有效抑制新冠病毒，徐华强/张抒扬/余学奎/张磊砢合作解析新冠病毒复制酶与苏拉明复合物结构
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• Rapid detection of SARS-CoV-2, replicating or non-replicating, using RT-PCR
• 【研究】紫外线照明可在几秒钟内消灭新冠病毒
• UV-C lighting is proving its public health value in the fight against coronavirus
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• Emergence of a SARS-CoV-2 variant of concern with mutations in spike glycoprotein
• Science新冠专题｜引起重症新冠肺炎患者过度免疫反应的潜在因素：辅助性T细胞群
• Clonal expansion and activation of tissue-resident memory-like Th17 cells expressing GM-CSF in the lungs of severe COVID-19 patients
• 石正丽：新冠病毒的祖先在哪？
• NSMB | 徐华强/张抒扬/余学奎/张磊砢合作解析新冠病毒复制酶与苏拉明复合物结构
• 蝙蝠冠状病毒RaTG13和穿山甲冠状病毒PCoV_GX刺突蛋白结构首次被解析！为理解新冠病毒的进化提供线索
• Bat and pangolin coronavirus spike glycoprotein structures provide insights into SARS-CoV-2 evolution
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• Virus-Host Interactome and Proteomic Survey Reveal Potential Virulence Factors Influencing SARS-CoV-2 Pathogenesis
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• Integrated cytokine and metabolite analysis reveals immunometabolic reprogramming in COVID-19 patients with therapeutic implications
• 啥？草泥马竟然携带了对抗新冠的秘密武器
• Versatile and multivalent nanobodies efficiently neutralize SARS-CoV-2
• Cell: 比起原始新冠病毒, 3种南非新冠突变株抵抗疫苗中和力高达40倍
• COVID-19-neutralizing antibodies predict disease severity and survival
• Nature：英国、南非新冠突变对疫苗实际影响揭晓
• Antibody Resistance of SARS-CoV-2 Variants B.1.351 and B.1.1.7
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• SARS-CoV-2 Molecular Transmission Clusters and Containment Measures in Ten European Regions During the First Pandemic Wave
• Assessment of dengue and COVID-19 antibody rapid diagnostic tests cross-reactivity in Indonesia
• Nature：新冠英国突变株，相关死亡风险增加了61%
• Cell Reports：新冠病毒S蛋白线性表位全景图
• Linear epitope landscape of the SARS-CoV-2 Spike protein constructed from 1,051 COVID-19 patients
• 港大袁国勇Nature:减少病毒量逾九成！这种麻风病药物可有效治疗新冠？
• Clofazimine broadly inhibits coronaviruses including SARS-CoV-2
• Nature突破 | 袁国勇等团队首次发现廉价抗麻风药氯法齐明有抑制冠状病毒活性，对于控制新冠大流行可能发挥作用
• 麻风药物可在仓鼠模型中抑制新冠病毒 |《自然》论文
• 警惕！此国发现的新毒株，可逃避核酸检测！
• Cell Res | 连发2篇！西湖大学周强等团队系统揭示新冠刺突蛋白活化的机制及中和单克隆抗体起作用的机制
• Structural basis for bivalent binding and inhibition of SARS-CoV-2 infection by human potent neutralizing antibodies
• Structural basis for the different states of the spike protein of SARS-CoV-2 in complex with ACE2
• Simulation of aerosol transmission on a Boeing 737 airplane with intervention measures for COVID-19 mitigation
• Molecular Analysis of SARS-CoV-2 Genetic Lineages in Jordan: Tracking the Introduction and Spread of COVID-19 UK Variant of Concern at a Country Level
• Critical ACE2 Determinants of SARS-CoV-2 and Group 2B Coronavirus Infection and Replication
• Immunogenicity of prime-boost protein subunit vaccine strategies against SARS-CoV-2 in mice and macaques
• Genomic characterization and phylogenetic analysis of the first SARS-CoV-2 variants introduced in Lebanon
• 通缉！哪些动物容易感染新冠病毒？
• The search for animals harbouring coronavirus — and why it matters
• EMBO J：研究揭示肺脏抵抗病毒感染的机制
• Non‐canonical autophagy functions of ATG16L1 in epithelial cells limit lethal infection by influenza A virus
• Science：新研究揭示大多数SARS-CoV-2变体很少通过二次传播持续存在
• SARS-CoV-2 within-host diversity and transmission
• 关于变异病毒的更新信息
• 重磅：云南省蝙蝠揭示冠状病毒复杂的进化史！
• Identification of novel bat coronaviruses sheds light on theevolutionary origins of SARS-CoV-2 and related viruses
• 这个变异令新冠致死率提高了55%！中国曾出现多例…张文宏最新发声：不打疫苗会吃亏！
• Cell论文解读！新研究揭示突变如何让新冠病毒逃避免疫防御
• SARS-CoV-2 evolution in an immunocompromised host reveals shared neutralization escape mechanisms
• 中科院微生物所王军研究组在新冠病人肠道病毒组研究领域取得新进展
• Integrated Gut Virome and Bacteriome Dynamics in COVID-19 Patients
• 动动手指，按下开关，病毒秒灭？紫外线消毒灯没那么神！
• Cell Research | 游富平/王祥喜合作揭示新型冠状病毒S蛋白直接结合并激活TLR4诱发抗细菌样天然免疫和病毒性脓毒症
• SARS-CoV-2 spike protein interacts with and activates TLR4
• Genomic diversity of SARS-CoV-2 during early introduction into the Baltimore–Washington metropolitan area
• 广东疾控中心首席专家：新冠病毒尼日利亚突变株传播力强 疫苗有效性尚需观察
• Nature：双特异性抗体可中和治疗抵抗性的新冠病毒变种
• Bispecific IgG neutralizes SARS-CoV-2 variants and prevents escape in mice
• Double antibody against SARS-CoV-2 prevents therapy-resistant variants
• 斯坦福科学家开源了莫德纳mRNA新冠疫苗的基因测序，在GitHub上
• Assemblies-of-putative-SARS-CoV2-spike-encoding-mRNA-sequences-for-vaccines-BNT-162b2-and-mRNA-1273
• SARS-CoV-2 N501Y Introductions and Transmissions in Switzerland from Beginning of October 2020 to February 2021—Implementation of Swiss-Wide Diagnostic Screening and Whole Genome Sequencing
• Genome Sequences of Three SARS-CoV-2 P.1 Strains Identified from Patients Returning from Brazil to Italy
• 朱凤才/王祥喜/秦成峰合作基于中和抗体免疫特性反向设计并开发新一代新冠病毒基因工程疫苗
• A proof of concept for neutralizing antibody-guided vaccine design against SARS-CoV-2
• Science新冠专题｜针对英国约1000人的SARS-CoV-2突变分析
• SARS-CoV-2 within-host diversity and transmission
• 病毒从动物传入到人，到华南海鲜市场疫情的暴发可能经历了很长的时间——中国-世界卫生组织新冠病毒溯源联合研究中方专家组介绍有关情况
• Soluble ACE2-mediated cell entry of SARS-CoV-2 via interaction with proteins related to the renin-angiotensin system
• mRNA vaccination boosts cross-variant neutralizing antibodies elicited by SARS-CoV-2 infection
• COVID‐19: emergence and mutational diversification of SARS‐CoV‐2
• Antibody responses to the BNT162b2 mRNA vaccine in individuals previously infected with SARS-CoV-2
• 重组蛋白疫苗：接种者中和抗体水平是康复患者两倍
• Cell：新研究表明新冠病毒变种B.1.351和P.1逃避中和抗体
• SARS-CoV-2 variants B.1.351 and P.1 escape from neutralizing antibodies
• Evidence for reduced antibody protection against SARS-CoV-2 variants
• Plos Pathog.：病毒分类被忽视的根源
• Recognizing species as a new focus of virus research
• Gut | 郑州大学等多单位合作，李兰娟/余祖江/任志刚首次发现新冠患者口腔微生物组成发生改变
• Alterations in the human oral and gut microbiomes and lipidomics in COVID-19
• Critical ACE2 Determinants of SARS-CoV-2 and Group 2B Coronavirus Infection and Replication
• Coronavirus-Specific Antibody Cross Reactivity in Rhesus Macaques Following SARS-CoV-2 Vaccination and Infection
• Surveillance of SARS-CoV-2 in Frankfurt am Main from October to December 2020 Reveals High Viral Diversity Including Spike Mutation N501Y in B.1.1.70 and B.1.1.7
• 【Applied Energy最新原创论文】一种用于空间加热和病毒灭活的新型消毒特隆布墙：概念和性能研究
• A novel disinfected Trombe wall for space heating and virus inactivation: Concept and performance investigation
• SARS-CoV-2 seroprevalence study in Lambayeque, Peru. June–July 2020
• Nature：从多个视角观察新冠病毒感染细胞的全过程
• Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV
• 【深读】mRNA技术会改变世界吗？
• 王林发: 又一蝙蝠病毒被发现，具备跨种传播能力
• Achimota Pararubulavirus 3: A New Bat-Derived Paramyxovirus ofthe Genus Pararubulavirus
• COVID-19轻重症患者代谢组学特征，发现重症患者重要生物标志物
• Multi-platform omics analysis reveals molecular signature for COVID-19 pathogenesis, prognosis and drug target discovery
• 最新研究 | COVID-19变异株B.1.1.7虽然传播能力更强，但并未增加疾病严重性
• Changes in symptomatology, reinfection, and transmissibility associated with the SARS-CoV-2 variant B.1.1.7: an ecological study
• Genomic characteristics and clinical effect of the emergent SARS-CoV-2 B.1.1.7 lineage in London, UK: a whole-genome sequencing and hospital-based cohort study
• 武汉病毒所/国家病毒资源库等在SARS-CoV-2感染诱导的持续性体液免疫应答研究中取得新进展
• SARS-CoV-2 infection induces sustained humoral immune responses in convalescent patients following symptomatic COVID-19
• 戴两口罩，管用吗？
• Fitted Filtration Efficiency of Double Masking During the COVID-19 Pandemic
• Genome Sequences of Three SARS-CoV-2 P.1 Strains Identified from Patients Returning from Brazil to Italy
• Cross-reactivity of two SARS-CoV-2 serological assays in a malaria-endemic setting
• Interim Estimates of Vaccine Effectiveness of BNT162b2 and mRNA-1273 COVID-19 Vaccines in Preventing SARS-CoV-2 Infection Among Health Care Personnel, First Responders, and Other Essential and Frontline Workers — Eight U.S. Locations, December 2020–March 2021
• Lack of cross-transmission of SARS-CoV-2 between passenger's cabins on the Diamond Princess cruise ship
• BNT162b2 Vaccination Effectively Prevents the Rapid Rise of SARS-CoV-2 Variant B. 1.1. 7 in high risk populations in Israel
• Monitoring differences between the SARS-CoV-2 B.1.1.7 variant and other lineages
• Neutralizing antibody responses after SARS-CoV-2 infection in end-stage kidney disease and protection against reinfection
• SARS-CoV-2: The viral shedding vs infectivity dilemma
• 新冠症状轻重的免疫机制：肺泡巨噬细胞抑制或促进病毒感染的两面性
• Distinct uptake, amplification, and release of SARS-CoV-2 by M1 and M2 alveolar macrophages
• Genome Sequences of Three SARS-CoV-2 P.1 Strains Identified from Patients Returning from Brazil to Italy
• SARS-CoV-2 escape mutants and protective immunity from natural infections or immunizations
• An intra-host SARS-CoV-2 dynamics model to assess testing and quarantine strategies for incoming travelers, contact person management and de-isolation
• 谁能想到，研发艾滋疫苗的技术，却先用在了新冠疫苗上
• Transmission Dynamics of SARS-CoV-2 Within-Host Diversity in Two Major Hospital Outbreaks in South Africa
• A novel linker-immunodominant site (LIS) vaccine targeting the SARS-CoV-2 spike protein protects against severe COVID-19 in Syrian hamsters
• 持续了数千年! 2.5万年前一种古老冠状病毒曾袭击东亚, 暴发类似新冠的疫情
• 研究发现COVID-19冠状病毒在人与猫间传播的新证据
• 新冠病毒核衣壳蛋白通过相变促进宿主炎症反应的新机制
• RNA-induced liquid phase separation of SARS-CoV-2 nucleocapsid protein facilitates NF-κB hyper-activation and inflammation
• Susceptibility to SARS-CoV-2 of Cell Lines and Substrates Commonly Used to Diagnose and Isolate Influenza and Other Viruses
• 中山大学杨欣团队WR：基于核酸的碱基序列预测紫外光照下的病毒灭活速率
• Prediction of Photolysis Kinetics of Viral Genomes under UV254 Irradiation to Estimate Virus Infectivity Loss
• 钟南山在基金委期刊发文：阐述人类和ACE2人源化小鼠对SARS-CoV-2的免疫反应
• Immune responses to SARS-CoV-2 infection in Humans and ACE2 humanized mice
• STTT：崔隽/赵金存等揭示新冠核衣壳蛋白通过相变促进宿主炎症反应新机制
• “病毒-人类”混合DNA？新研究称新冠病毒可整合到人类基因组中
• Reverse-transcribed SARS-CoV-2 RNA can integrate into the genome of cultured human cells and can be expressed in patient-derived tissue
• Science/PNAS | 中国学者参与，2顶尖实验室联手合作，发现新冠病毒基因可以整合到人类基因组中
• Further evidence supports controversial claim that SARS-CoV-2 genes can integrate with human DNA
• 新冠可写入人类基因组，成为永不灭亡的病毒？
• Immunity | 西湖大学等多单位合作，谢琦/丁思远等发现新冠病毒引起人体炎症反应的潜在机理
• SARS-CoV-2 exacerbates proinflammatory responses in myeloid cells through C-type lectin receptors and Tweety family member 2
• Differential role of sphingomyelin in influenza virus, rhinovirus and SARS-CoV-2 infection of Calu-3 cells
• 让疫苗接种者再感染、推动印度新一轮疫情的变异株有多可怕？
• Coronavirus variants are spreading in India — what scientists know so far
• 新冠病毒RNA可插入人类染色体DNA？新证据引发对mRNA疫苗安全性担忧
• ​南开大学郭宇/张宏恺/饶子和：高亲和力的新冠病毒（SARS-CoV-2）中和抗体展现良好的治疗潜力
• A SARS-CoV-2 neutralizing antibody with exceptional spike binding coverage and optimized therapeutic potentials
• SARS-CoV-2 Infections in Animals: Reservoirs for Reverse Zoonosis and Models for Study
• Comparable endemic coronavirus nucleoprotein‐specific antibodies in mild and severe Covid‐19 patients
• 又一篇！南开大学郭宇/张宏恺/饶子和发现结合新型表位的SARS-CoV-2中和抗体
• Structural basis for SARS-CoV-2 neutralizing antibodies with novel binding epitopes
• Coronavirus seroprevalence among villagers exposed to bats in Thailand
• Recombinant GII.P16 genotype challenges RT-PCR-based typing in region A of norovirus genome
• Nature子刊 | 中山大学陈守登／单鸿／肖非／廖化新团队发现首个可抑制COVID-19补体过度激活的全人源新冠病毒N蛋白抗体
• A SARS-CoV-2 antibody curbs viralnucleocapsid protein-induced complement hyperactivation
• Nature视频 | 关于新冠病毒变异株的几个真相
• 视频文字稿 | 关于新冠病毒变异株的几个真相
• Science杂志最新论文：新研究发现冠状病毒“致命弱点”
• STTT | 南方医科大学侯凡凡​/侯金林系统评估新冠患者中和抗体对新冠病毒反应的动力学
• Dynamics of neutralizing antibody responses to SARS-CoV-2 in patients with COVID-19: an observational study
• Viral dynamics and antibody responses in people with asymptomatic SARS-CoV-2 infection
• Inactivation of SARS-CoV-2 Laboratory Specimens
• Nature子刊 | 中山大学陈守登／单鸿／肖非／廖化新发现首个可抑制COVID-19补体过度激活的全人源新冠病毒N蛋白抗体
• 吴尊友：安徽和辽宁病例的病毒基因测序完全相同，病毒一定来自境外！
• 新冠病毒 SARS-CoV-2的S蛋白本身即可引起血管内膜炎
• SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE 2
• 发现两种全新的可感染人类的冠状病毒，分别来自狗和猪
• Two more coronaviruses can infect people, studies suggest
• A molecularly engineered, broad-spectrum anti-coronavirus lectin inhibits SARS-CoV-2 and MERS-CoV infection in vivo
• Mining of linear B cell epitopes of SARS-CoV-2 ORF8 protein from COVID-19 patients
• Protein & Cell丨吴爱平/秦成峰团队评述新冠病毒在人和动物中的趋同进化
• Convergent evolution of SARS-CoV-2 in human and animals
• 快报：石正丽团队发现一种新型冠状病毒
• Identification of a novel lineage bat SARS-related coronaviruses that use bat ACE2 receptor
• 中国学者连发3篇Cell！高福、饶子和等团队在冠状病毒领域取得新进展
• Binding and molecular basis of the bat coronavirus RaTG13 virus to ACE-2 in humans and other species
• Coupling of N7-methyltransferase and 3'-5' exoribonuclease with SARS-CoV-2 polymerase reveals mechanisms for capping and proofreading
• An infectivity-enhancing site on the SARS-CoV-2 spike protein targeted by antibodies
• Cell | 饶子和/娄智勇/高岩合作阐明新冠病毒mRNA合成、基因组复制矫正和逃逸核苷类抗病毒药物的分子机制
• 再发Cell|高福团队在冠状病毒跨物种传播研究领域取得重大进展
• Sequential infection with H1N1 and SARS-CoV-2 aggravated COVID-19 pathogenesis in a mammalian model, and co-vaccination as an effective method of prevention of COVID-19 and influenza
• Tracking the international spread of SARS-CoV-2 lineages B.1.1.7 and B.1.351/501Y-V2
• 新的人类冠状病毒CCOV-HuPn-2018被确认：起源于犬类
• Cell: 发现一组抗聚糖抗体可有效地中和HIV病毒
• Fab-dimerized glycan-reactive antibodies are a structural category of natural antibodies
• Cell Res. | 谢晓亮团队揭示不同类型新冠疫苗对突变株体液免疫应答情况
• Humoral immune response to circulating SARS-CoV-2 variants elicited by inactivated and RBD-subunit vaccines
• 警惕！新冠病毒之外，又发现两种全新冠状病毒可以感染人类
• 《Nature》：科学家对新冠变体B.1.617的新认知！
• What scientists know about new, fast-spreading coronavirus variants
• Cell：感染SARS-CoV-2不仅会产生预防感染的中和抗体，还会产生增强感染的抗体
• An infectivity-enhancing site on the SARS-CoV-2 spike protein targeted by antibodies
• 证实了！新冠病毒可引发ADE效应，群体自然免疫破产
• An infectivity enhancing site on the SARS-CoV-2 spike protein targeted by antibodies
• Science :为什么新冠病毒难防？原来它容易发生这3种关键突变！
• Structural and functional ramifications of antigenic drift in recent SARS-CoV-2 variants
• B.1.617变异株传播速度多快？疫苗还有效吗？
• What scientists know about new, fast-spreading coronavirus variants
• 结论反转？新冠病毒RNA并不能逆转录转座整合到人类基因组中
• Reverse-transcribedSARS-CoV-2 RNA can integrate into the genome of cultured human cells and can beexpressed in patient-derived tissues
• Human genomeintegration of SARS-CoV-2 contradicted by long-read sequencing
• Cell:饶子和、娄智勇团队阐明新冠病毒mRNA合成、基因组复制矫正和逃逸核苷类抗病毒药物的分子机制
• Coupling of N7-methyltransferase and 3'-5' exoribonuclease with polymerase reveals mechanisms for capping and proofreading
• 为何新冠病毒会破坏肺部？原因找到了！
• 新冠全球溯源研究中国部分公布：部分疑似阳性样本检测时间早于武汉首例病例
• 米兰国家肿瘤研究所：意大利2019年血液样本检测结果无法解释新冠病毒起源
• 「武汉市大流行初期就已存在一定的病毒多样性，说明华南海鲜市场外还有未采样的传播链」——世卫召集的SARS-CoV-2全球溯源研究
• Cell重磅 |史卫峰等团队揭示了 SARS-CoV-2 和相关病毒的进化起源，蝙蝠？还是...
• Identification of novel bat coronaviruses sheds light on the evolutionary origins of SARS-CoV-2 and related viruses
• 世卫重检意大利2019年血样 更多研究发现改写新冠疫情时间线
• 清华大学阐明新冠病毒突变株中和抗体逃逸机制
• Analysis of SARS-CoV-2 variant mutations reveals neutralization escape mechanisms and the ability to use ACE2 receptors from additional species
• CDC周报：广州深圳“5·21”疫情毒株分析
• Notes from the Field: Genome Characterization of COVID-19 Lineage B.1.1.7 Detected in the First Six Patients of a Cluster Outbreak — Shenzhen City, Guangdong Province, China, May 2021
• Molecular evidence of SARS-CoV-2 in New York before the first pandemic wave
• 看清新冠病毒入侵人体瞬间，西湖大学研究获浙江自然科学奖一等奖
• 石正丽接受《纽约时报》访问：新冠病毒实验室泄漏说毫无根据
• 冠状病毒可通过触发程序性细胞死亡而获得致病优势｜Science Advances
• Targeting highly pathogenic coronavirus-induced apoptosis reduces viral pathogenesis and disease severity
• NIH最新研究：新冠病毒2019年12月已在美国出现，早于武汉疫情暴发
• 苏黎世联邦理工学院Nature Nanotechnology：高效灭活各种病毒的一张膜，包括新冠病毒
• An antiviral trap made of protein nanofibrils and iron oxyhydroxide nanoparticles
• Viruses：石正丽课题组在中国蝙蝠种群中发现新型弹状病毒
• Characterization of Novel Rhabdoviruses in Chinese Bats
• 管轶：要做好应对新冠变异病毒的长期准备
• Cell子刊：HIV和新冠病毒的进化比对
• HIV-1 and SARS-CoV-2: Patterns in the Evolution ofTwo Pandemic Pathogens
• 与细胞表面受体结合更强！印度新出现的“德尔塔+”令人担忧...
• Union Health Ministry advises Maharashtra, Kerala and Madhya Pradesh on Delta Plus Variant, currently a Variant of Concern (VOC)
• 最新答案：哪种免疫原更适合新冠疫苗研发
• 病毒才是生物界的“游戏玩家”高手！Science |最新发文揭示病毒进化的奥秘
• Evolution of a virus-like architecture and packaging mechanism in a repurposed bacterial protein
• Impact of Prior Influenza and Pneumoccocal Vaccines on Humoral and Cellular Response to SARS-CoV-2 BNT162b2 Vaccination
• Cell：清华饶子和团队解析新冠病毒复制校正和mRNA加帽机制 | Cell Press对话科学家
• Coupling of N7-methyltransferase and 3′-5′ exoribonuclease with SARS-CoV-2 polymerase reveals mechanisms for capping and proofreading
• 人类粪便中发现54118种病毒：90%以上前所未知，大多数不会攻击人体
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• 新冠病毒变异株中和抗体研发取得突破
• Second-Generation Antibodies Neutralize Emerging SARS-CoV-2 Variants of Concern
• 传播快、易耐药、多重症：Delta株有多难缠？
• Delta coronavirus variant: scientists brace for impact
• 重要发现：宿主内多样性是新冠病毒进化的主要阶段
• One viral sequence for each host? – The neglected within-host diversity as the main stage of SARS-CoV-2 evolution
• Detection of R.1 lineage severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with spike protein W152L/E484K/G769V mutations in Japan
• p- cymene impairs SARS- CoV- 2 and Influenza A (H1N1) viral replication: In silico predicted interaction with SARS- CoV- 2 nucleocapsid protein and H1N1 nucleoprotein
• SARS-CoV-2 Seroprevalence and Neutralizing Antibody Response after the First and Second COVID-19 Pandemic Wave in Croatia
• 100名医务人员发生疫苗突破性感染！Delta病毒有多凶猛？
• 德尔塔变体存在“免疫逃逸”也不怕！研究发现疫苗可让T细胞成为最后一道防线
• Impact of SARS-CoV-2 variants on the total CD4+ and CD8+ T cell reactivity in infected or vaccinated individuals
• 《Nature》COVID-19疫苗通过持续的生发中心反应诱导了持续免疫
• SARS-CoV-2 mRNA vaccines induce persistent human germinal centre responses
• 税光厚/王福生/张福杰团队用多组学方法揭示新冠患者在不同感染阶段的血浆外囊泡的组成和功能
• A multi-omics investigation of the composition and function of extracellular vesicles along the temporal trajectory of COVID-19
• Nature子刊：人畜共用疫苗开发的机遇与挑战
• Using cross-species vaccination approaches to counter emerging infectious diseases
• Comparing Results of Five SARS-CoV-2 Antibody Assays Before and After the First Dose of ChAdOx1 nCoV-19 Vaccine among Health Care Workers
• An ACE2 Triple Decoy that neutralizes SARS-CoV-2 shows enhanced affinity for virus variants
• Seroprevalence of SARS-CoV-2 Antibodies in Symptomatic Individuals Is Higher than in Persons Who Are at Increased Risk Exposure: The Results of the Single-Center, Prospective, Cross-Sectional Study
• Protection of K18-hACE2 mice and ferrets against SARS-CoV-2 challenge by a single-dose mucosal immunization with a parainfluenza virus 5–based COVID-19 …
• Viruses：揭开SARS-CoV-2刺突蛋白突变的神秘面纱
• The Spike of Concern—The Novel Variants of SARS-CoV-2
• Molecular surveillance of the on-going SARS-COV-2 epidemic in Ribeirao Preto City, Brazil
• Fusion Protein of Rotavirus VP6 and SARS-CoV-2 Receptor Binding Domain Induces T Cell Responses
• 衰老和COVID-19的细胞和蛋白质组学分析 | 《自然-衰老》六月刊
• Nature | 花样病毒如此多娇
• Beyond coronavirus: the virus discoveries transforming biology
• The molecular basis for SARS-CoV-2 binding to dog ACE2
• Broad spectrum anti-coronavirus activity of a series of anti-malaria quinoline analogues
• Cell重磅：新冠病毒跨物种传播的关键突变被发现
• A selective sweep in the Spike gene has driven SARS-CoV-2 human adaptatio
• An outbreak caused by the SARS-CoV-2 Delta (B.1.617.2) variant in a care home after partial vaccination with a single dose of the COVID-19 vaccine Vaxzevria, London, England, April 2021
• Science：重大进展！哺乳动物干细胞可利用抗病毒Dicer抵御多种RNA病毒入侵
• An isoform of Dicer protects mammalian stem cells against multiple RNA viruses
• 重磅！关于新冠起源，20余位中国科学家郑重发声！
• On the origin of SARS-CoV-2—The blind watchmaker argument
• 清华大学张林琦团队揭示新冠病毒中和逃逸机制 | CellPress对话科学家
• Analysis of SARS-CoV-2 variant mutations reveals neutralization escape mechanisms and the ability to use ACE2 receptors from additional species
• 昆士兰大学郭建华团队ES&T Letters：新型多重扩增子测序法实现污水中SARS-CoV-2 RNA的精确定量和病毒溯源
• Novel Multiplexed Amplicon-Based Sequencing to Quantify SARS-CoV-2 RNA from Wastewater
• 没完了！变异新冠病毒开始杂交，不同种类一起进攻，在人体内混合
• Science子刊：打新冠疫苗后保护率怎样？这个灵敏度为96.7%的新方法能监测
• A high-throughput cell- and virus-free assay shows reduced neutralization of SARS-CoV-2 variants by COVID-19 convalescent plasma
• 清华大学李丕龙课题组开发基于相变的互作筛选新技术并揭示新型冠状病毒高阶蛋白复合物的组成
• 《Nature Medicine》“组合体”显示SARS-CoV-2如何感染脑细胞
• A human three-dimensional neural-perivascular ‘assembloid’ promotes astrocytic development and enables modeling of SARS-CoV-2 neuropathology
• Serum Neutralizing Activity against B.1.1.7, B.1.351, and P.1 SARS-CoV-2 Variants of Concern in Hospitalized COVID-19 Patients
• 万能的“剪刀手”！——基因编辑技术可高效阻止新冠病毒及其变体在细胞中复制
• Reprogrammed CRISPR-Cas13b suppresses SARS-CoV-2 replication and circumvents its mutational escape through mismatch tolerance
• 武汉病毒所：RaTG13和新冠病毒之间的进化距离大约是20年到50年
• Molecular surveillance of the on-going SARS-COV-2 epidemic in Ribeirao Preto City, Brazil
• Primary, Recall, and Decay Kinetics of SARS-CoV-2 Vaccine Antibody Responses
• SARS-CoV-2 B.1.617.2 Delta variant emergence, replication and sensitivity to neutralising antibodies
• Nationwide Seroprevalence of SARS-CoV-2 IgG Antibodies among Four Groups of Primary Health-Care Workers and Their Household Contacts 6 Months after the Initiation of the COVID-19 Vaccination Campaign in France: SeroPRIM Study Protocol
• 重组蛋白亚基新冠疫苗在三种动物试验中安全有效｜Science新冠专题
• A recombinant spike protein subunit vaccine confers protective immunity against SARS-CoV-2 infection and transmission in hamsters
• 病毒载量增加1260倍！Delta毒株的传播速度为何这么快？
• How the Delta variant achieves its ultrafast spread
• STTT | 广州医科大学等多单位合作，张康/项鹏等系统评估新冠病毒变体 CAL.20C 免疫血清的传染性及其对中和活性的影响
• Assessment of infectivity and the impact on neutralizing activity of immune sera of the COVID-19 variant, CAL.20C
• 席卷全球的Delta新冠变种传染性这么强，究竟是什么原因？
• Variant Analysis of SARS-CoV-2 Genomes from Belgian Military Personnel Engaged in Overseas Missions and Operations
• Secreted Expression of mRNA-Encoded Truncated ACE2 Variants for SARS-CoV-2 via Lipid-Like Nanoassemblies
• Replicative Fitness of a SARS-CoV-2 20I/501Y.V1 Variant from Lineage B.1.1.7 in Human Reconstituted Bronchial Epithelium
• Murine Monoclonal Antibodies against the Receptor Binding Domain of SARS-CoV-2 Neutralize Authentic Wild-Type SARS-CoV-2 as Well as B.1.1.7 and B.1.351 Viruses and Protect In Vivo in a Mouse Model in a Neutralization-Dependent Manner
• 新冠病毒如何感染细胞？Delta为何这么毒？|《自然》长文
• How the coronavirus infects cells — and why Delta is so dangerous
• Nat Commun | 靶向新冠病毒RBD的纳米抗体可有效预防仓鼠感染 ​
• A synthetic nanobody targeting RBD protects hamsters from SARS-CoV-2 infection
• Cell Research | 黄超兰/高福合作团队描绘新冠病毒S蛋白糖基化修饰图谱，揭示“O-Follow-N”糖基化新规律
• O-glycosylation pattern of the SARS-CoV-2 spike protein reveals an “O-Follow-N” rule
• “德尔塔”毒株来袭！如何做到快速分离检测到新冠病毒？
• “疫情初始暴发地不一定是起源地”｜高福院士等发表新冠病毒溯源新成果
• Tracing the origin of SARS-CoV-2: lessons learned from the past
• 最危险的突变株拉姆达出现？传染性和免疫抵抗力同时增强，已在数十个国家广泛传播
• SARS-CoV-2 Lambda variant exhibits higher infectivity and immune resistance
• 新冠变异株“德尔塔”三次闯关，这次有何不同？
• 感染318天, 体内变异40次 俄科学家: 新冠病毒把人体当成了“健身房”
• 复旦大学余宏杰课题组在新冠病毒变异株的免疫逃避研究领域取得进展
• Neutralizing antibodies against SARS-CoV-2 variants induced by natural infection or vaccination: a systematic review and pooled meta-analysis
• Evolution and Epidemic Spread of SARS-CoV-2 in Colombia: A Year into the Pandemic
• Changing composition of SARS-CoV-2 lineages and rise of Delta variant in England
• 新型突变株“拉姆达”来袭: 进一步对疫苗产生抗性
• 访谈｜德尔塔突变株会改变 “清零” 防控策略吗？
• Neutralizing Activity of Sera from Sputnik V-Vaccinated People against Variants of Concern (VOC: B.1.1.7, B.1.351, P.1, B.1.617.2, B.1.617.3) and Moscow Endemic SARS-CoV-2 Variants
• 清华李丕龙团队巧用相变招募新技术绘制新冠病毒蛋白互作网络 | Cell Press对话科学家
• Compartmentalization-aided interaction screening reveals extensive high-order complexes within the SARS-CoV-2 proteome
• 孙强/黄红艳团队合作揭示N501Y突变赋予新冠病毒感染小鼠能力
• N501Y mutation imparts cross-species transmission of SARS-CoV-2 to mice by enhancing receptor binding
• A novel SARS-CoV-2 related coronavirus with complex recombination isolated from bats in Yunnan province, China
• Genetic analysis and biological characteristics of novel clade 2.3.4.4 reassortant H5N6 avian influenza viruses from poultry in Eastern China in 2016
• 新冠变异株这么多，为什么是德尔塔最流行？
• Why Do Variants Such as Delta Become Dominant?
• 溯源！美国野生动物于2019年发现新冠抗体！
• 寻找导致新冠重症的基因 |《自然》长文
• The quest to find genes that drive severe COVID
• Nat Comm | 新冠病毒RNA假结具有多种折叠结构
• Structural dynamics of single SARS-CoV-2 pseudoknot molecules reveal topologically distinct conformers
• 中国科学家联合报道：新冠病毒RNA不具备整合进宿主基因组的能力
• Comprehensive analysis of RNA-seq and whole genome sequencing data reveals no evidence for SARS-CoV-2 integrating into host genome
• No evidence of human genome integration of SARS-CoV-2 found by long-read DNA sequencing
• Somatic coliphages are conservative indicators of SARS-CoV-2 inactivation during heat and alkaline pH treatments
• The unique evolutionary dynamics of the SARS-CoV-2 Delta variant
• No species-level losses of s2m suggests critical role in replication of SARS-related coronaviruses
• Jumping a Moving Train: SARS-CoV-2 Evolution in Real Time
• 华科薛宇教授团队合作绘制新冠肺炎逝者多器官蛋白质图谱
• Postmortem Tissue Proteomics Reveals the Pathogenesis of Multiorgan Injuries of COVID-19
• Live attenuated coronavirus vaccines deficient in N7-Methyltransferase activity induce both humoral and cellular immune responses in mice
• High throughput diagnostics and dynamic risk assessment of SARS-CoV-2 variants of concern
• 新冠病毒方兴未艾，超级真菌又来雪上加霜？丨微生物的那些事儿
• The Alpha Variant (B. 1.1. 7) of SARS-CoV-2 in Children: First Experience from 3544 Nucleic Acid Amplification Tests in a Cohort of Children in Germany
• SCLS｜魏文胜课题组和合作者报道新冠病毒新型潜在受体发现
• Genome-wide CRISPR activation screen identifies candidate receptors for SARS-CoV-2 entry
• 病毒从武汉病毒所实验室泄露？ 美英等国21位权威专家：无任何科学证据
• 病毒是怎么变异的？人类能消灭它吗？| 病毒超话
• “打败艾滋病的人”何大一，发表2篇Nature论文，揭示高致死率新冠毒株B.1.526的出现，传播及免疫特征
• Emergence and expansion of SARS-CoV-2 B.1.526 after identification in New York
• Antibody Resistance of SARS-CoV-2 Variants B.1.351 and B.1.1.7
• Comparison of SARS-CoV-2-and HCoV-Specific T Cell Response Using IFN-γ ELISpot
• 应用进化动力学结合病毒学研究，追踪新冠病毒起源和进化特征 | Infectious Diseases of Poverty
• Characterization of SARS-CoV-2 worldwide transmission based on evolutionary dynamics and specific viral mutations in the spike protein
• 赵玉芬/韩家淮合作揭示新冠S蛋白通过ACE2诱导细胞融合形成多核体引发细胞焦亡的
• Pyroptosis of syncytia formed by fusion of SARS-CoV-2 Spike and ACE2 expressing cells
• Cell Research | 肖俊宇、谢晓亮团队联合发现针对新冠病毒突变株的强效全人源广谱中和抗体组合
• Structures of SARS-CoV-2 B.1.351 neutralizing antibodies provide insights into cocktail design against concerning variants
• 新冠突变株传播力为何增强？清华谭旭团队揭示新冠流行变种具有逃逸人体细胞免疫的普遍特点
• Profiling CD8+ T Cell Epitopes of COVID-19 Convalescents Reveals Reduced Cellular Immune Responses to SARS-CoV-2 Variants
• Comparative kinetics of SARS-CoV-2 anti-spike protein RBD IgGs and neutralizing antibodies in convalescent and naïve recipients of the BNT162b2 mRNA vaccine versus COVID-19 patients
• Neutralization of the SARS-CoV-2 Delta variant after heterologous and homologous BNT162b2 or ChAdOx1 nCoV-19 vaccination
• Science：包括新冠、流感、麻疹病毒在内的多数呼吸道病毒通过气溶胶传播
• Airborne transmission of respiratory viruses
• 新发现！新冠病毒或一周突变一次
• 挖掘病毒突变特征，实证支持新冠病毒自然起源 | 专家点评The Innovation
• Host-specific asymmetric accumulation of mutation types reveals that the origin of SARS-CoV-2 is consistent with a natural process
• 警惕！新的变异毒株“Mu”出现了，或有更高的疫苗耐受性
• 病毒溯源：新冠病毒是来源于蝙蝠病毒RaTG13吗？
• STTT | 重大进展！秦川团队首次发现新冠病毒可以穿过血脑屏障及感染大脑的分子机理
• SARS-CoV-2 crosses the blood–brain barrier accompanied with basement membrane disruption without tight junctions alteration
• NSR | 重大进展！秦成峰/吴仲义首次发现新冠病毒β变体可以感染小鼠
• Transient acquisition of cross-species infectivity during the evolution of SARS-CoV-2
• 南非出现新冠病毒C.1.2变异毒株，从源头上阻止病毒传播仍是防疫关键
• NSR | 重大进展！秦成峰/吴仲义首次发现新冠病毒β变体可以感染小鼠
• STTT | 重大进展！秦川团队首次发现新冠病毒可以穿过血脑屏障及感染大脑的分子机理
• Cell Res | 陈伟团队揭示生物力在新冠病毒入侵宿主过程中的重要作用
• Mechanical activation of spike fosters SARS-CoV-2 viral infection
• The self-assembled nanoparticle-based trimeric RBD mRNA vaccine elicits robust and durable protective immunity against SARS-CoV-2 in mice
• Outbreaks of SARS-CoV-2 in naturally infected mink farms: Impact, transmission dynamics, genetic pat
• SARS-CoV-2 B. 1.617. 2 Delta variant replication and immune evasion
• No species-level losses of s2m suggests critical role in replication of SARS-related coronaviruses
• Seroconversion and fever are dose-pependent in a nonhuman primate model of inhalational COVID-19
• 一种便携式新技术可在5分钟内准确检测出SARS-CoV-2抗体｜Science Advances
• Ultrafast, sensitive, and portable detection of COVID-19 IgG using flexible organic electrochemical transistors
• 新冠存在超长潜伏期吗？是否需要延长隔离期？病毒学专家给出研判
• Nature/STTT | 四川大学逯光文团队发现新冠病毒变体传染性增强的潜在机理
• S19W, T27W, and N330Y mutations in ACE2 enhance SARS-CoV-2 S-RBD binding toward both wild-type and antibody-resistant viruses and its molecular basis
• Nature/STTT | 四川大学逯光文团队发现新冠病毒变体传染性增强的潜在机理
• 钟南山团队: 新冠病毒中间宿主可能是啮齿类动物
• SARS-CoV-2：Origin， Intermediate Host and Allergenicity Features and Hypotheses
• 新冠病毒和老挝采集的菊头蝠冠状病毒有共同关键特征
• COVID-19唾液检测法的灵敏度有待提高
• Saliva Testing After COVID-19 Exposure
• 厦门大学夏宁邵教授团队发现能够抵御新冠病毒变异株的广谱中和抗体及其隐匿性表位
• Cross-neutralizing antibodies bind a SARS-CoV-2 cryptic site and resist circulating variants
• 高福：新冠病毒很可能在几十年前就藏匿在某个地方
• 研究：在中国发现的142种冠状病毒，都与新冠疫情无关
• 《科学》：类SARS病毒每年从动物传染人类可能达数十万次
• 刘国恩：新冠病毒按生物规律进化，人类没法一举消灭之
• Low SARS-CoV-2 Seroprevalence and No Active Infections among Dogs and Cats in Animal Shelters with Laboratory-Confirmed COVID-19 Human Cases among Employees
• The impact of co-circulating pathogens on SARS-CoV-2/COVID-19 Surveillance How concurrent epidemics may introduce bias and decrease the observed SARS-CoV-2 percent positivity
• Utilization of rapid antigen assays for detection of severe acute respiratory coronavirus virus 2 (SARS-CoV-2) in a low-incidence setting in emergency department triage: Does risk-stratification still matter?
• SARS-CoV-2 neutralizing antibodies decline after one year and patients with severe COVID-19 pneumonia display a unique cytokine profile
• Comparing immunoassays for SARS-Coronavirus-2 antibody detection in patients with and without laboratory-confirmed SARS-Coronavirus-2 infection
• S19W, T27W, and N330Y mutations in ACE2 enhance SARS-CoV-2 S-RBD binding toward both wild-type and antibody-resistant viruses and its molecular basis
• Emergence in late 2020 of multiple lineages of SARS-CoV-2 Spike protein variants affecting amino acid position 677
• Variants of SARS Coronavirus-2 and Their Potential Impact on the Future of the COVID-19 Pandemic
• Low dose inocula of SARS-CoV-2 Alpha variant transmits more efficiently than earlier variants in hamsters
• The Impact of Global Lineage Dynamics, Border Restrictions and Emergence of the B.1.1.7 Lineage on the SARS-CoV-2 Epidemic in Norway
• Structure-based analyses of neutralization antibodies interacting with naturally occurring SARS-CoV-2 RBD variants
• Identifying asymptomatic spreaders of antimicrobial-resistant pathogens in hospital settings
• 夏宁邵团队发现能够抵御新冠病毒变异株的广谱中和抗体和精确靶点
• Nature拳头综述（IF=61）| 上海科技大学杨海涛/饶子和发表新冠病毒结构生物学及其对治疗开发的影响的综述
• Structural biology of SARS-CoV-2 and implications for therapeutic development
• 柳叶刀：高福院士发表新冠病毒溯源最新观点
• The origins of viruses: discovery takes time, international resources, and cooperation
• 厦大研究团队发现能够抵御新冠病毒变异株的广谱中和抗体和精确靶点
• Science|全球联合研究探明能够阻止新冠病毒变异的抗体组合
• Definingvariant-resistant epitopes targeted by SARS-CoV-2 antibodies: A globalconsortium study
• Cell Research：新冠病毒溯源是重要科学问题
• 柳叶刀：高福院士发表新冠病毒溯源最新观点
• 研究人员发现以前未知的蛋白质参与 SARS-CoV-2感染
• 美国科学院院士：“德尔塔”或是新冠最后一个变异毒株
• Genomic sequencing of SARS-CoV-2 in Rwanda reveals the importance of incoming travelers on lineage diversity
• Genomic epidemiology reveals the reduction of the introduction and spread of SARS-CoV-2 after implementing control strategies in South Korea, 2020
• Multiple Occurrences of a 168-Nucleotide Deletion in SARS-CoV-2 ORF8, Unnoticed by Standard Amplicon Sequencing and Variant Calling Pipelines
• Cell Res | 袁钧瑛院士等团队首次发现新冠病毒促进 RIPK1 激活以便于病毒传播
• SARS-CoV-2 promotes RIPK1 activation to facilitate viral propagation
• 猕猴与蚊子 | 环境改变如何增加人畜共患疟疾向人类的传播？
• Macaques and mosquitoes
• SARS‐CoV‐2 neutralizing antibodies decline over one year and patients with severe COVID‐19 pneumonia display a unique cytokine profile
• Identification and characterization of SARS-CoV-2 clusters in the EU/EEA in the first pandemic wave: additional elements to trace the route of the virus
• Effect of Delta variant on viral burden and vaccine effectiveness against new SARS-CoV-2 infections in the UK
• Multiple Occurrences of a 168-Nucleotide Deletion in SARS-CoV-2 ORF8, Unnoticed by Standard Amplicon Sequencing and Variant Calling Pipelines
• Analysis of SARS-CoV-2 replication in explant cultures of the human upper respiratory tract reveals broad tissue tropism of wild-type and B.1.1.7 variant viruses
• Emergence and spread of SARS-CoV-2 lineage B.1.620 with variant of concern-like mutations and deletions
• 武汉病毒所在新冠病毒中和抗体复制型mRNA鼻腔递送研究中取得重要进展
• Intranasal delivery of replicating mRNA encoding neutralizing antibody against SARS-CoV-2 infection in mice
• 钟南山院士团队：SARS-CoV-2的起源、中间宿主和致敏性特征及假设 | MDPI Healthcare
• SARS-CoV-2: Origin, Intermediate Host and Allergenicity Features and Hypotheses
• Science |哈佛医学院研究揭示德尔塔病毒高传播能力
• 日本国立遗传学研究所：德尔塔病毒或趋于自然死亡，终结大流行钥匙？
• 朱轩 /陈福和/袁国勇团队最新研究进展：新冠病毒变异株跨越宿主屏障感染大鼠和小鼠
• Emerging SARS-CoV-2 variants expand species tropism to murines
• Science：Delta变体为何有高度传染性？诺奖得主团队有重磅发现！
• Rapid assessment of SARS-CoV-2 evolved variants using virus-like particles
• SARS-CoV-2 exploits host DGAT and ADRP for efficient replication
• Exponential growth, high prevalence of SARS-CoV-2, and vaccine effectiveness associated with the Delta variant
• Viral loads of Delta-variant SARS-CoV-2 breakthrough infections after vaccination and booster with BNT162b2
• BNT162b2 vaccination induces durable SARS-CoV-2 specific T cells with a stem cell memory phenotype
• Broad antiviral and anti-inflammatory activity of Qingwenjiere mixture against SARS-CoV-2 and other human coronavirus infections
• The effect of herd immunity thresholds on willingness to vaccinate against COVID-19
• 清华大学与中国医学科学院研究者合作解析病毒RNA与宿主蛋白质互作网络
• 钟南山院士团队：SARS-CoV-2的起源、中间宿主和致敏性特征及假设｜MDPI Healthcare
• SARS-CoV-2: Origin, Intermediate Host and Allergenicity Features and Hypotheses
• 美国情报部门正式发布新冠病毒起源评估报告
• Establishment of a specimen panel for the decentralised technical evaluation of the sensitivity of 31 rapid diagnostic tests for SARS-CoV-2 antigen, Germany, September 2020 to April 2021
• Beta RBD Boost Broadens Antibody-Mediated Protection Against SARS-CoV-2 Variants in Animal Models
• Protection against SARS-CoV-2 Beta Variant in mRNA-1273 Boosted Nonhuman Primates
• SARS-CoV-2 environmental contamination from hospitalised patients with COVID-19 receiving aerosol-generating procedures
• Evidence for retained spike-binding and neutralizing activity against emerging SARS-CoV-2 variants in serum of COVID-19 mRNA vaccine recipients
• SARS-CoV-2 environmental contamination from hospitalised patients with COVID-19 receiving aerosol-generating procedures
• Emergence of B. 1.524 (G) SARS-CoV-2 in Malaysia during the third COVID-19 epidemic wave
• Where have the enteric viruses gone? - Differential effects on frequent causes of infectious diarrhoea by SARS-CoV-2 pandemic lockdown measures
• Clusters of SARS-CoV-2 Lineage B.1.1.7 Infection after Vaccination with Adenovirus-Vectored and Inactivated Vaccines
• Reciprocal circulation pattern of SARS-CoV-2 and influenza viruses during the influenza seasons 2019/2020 and 2020/2021 in the Bavarian Influenza Sentinel (Germany)
• Nanoparticular CpG-adjuvanted SARS-CoV-2 S1 protein elicits broadly neutralizing and Th1-biased immunoreactivity in mice
• Nature|新型人畜共患病冠状病毒被发现
• 可能比德尔塔还可怕的新变异毒株来了！或从艾滋病患体内进化而来 中国香港已发现一例
• 世卫警示！新冠全新变体来袭，现有疫苗体系面临风险
• PNAS|新冠病毒的快速突变，结果好坏难预测
• SARS-CoV-2 evolution in animals suggests mechanismsfor rapid variant selection
• 清华丁强/王新泉团队合作揭示新冠病毒刺突蛋白Y453F突变增强对水貂ACE2结合的分子机制
• Mutation Y453F in the spike protein of SARS-CoV-2 enhances interaction with the mink ACE2 receptor for host adaption
• 令科学家警惕的Omicron变异株
• Heavily mutated Omicron variant puts scientists on alert
• 世卫答澎湃：已收到近百个新毒株序列报告，一些关键突变令人担忧
• 奥密克戎毒株“真面目”曝光，多国发现感染者
• Laboratory-Confirmed COVID-19 Among Adults Hospitalized with COVID-19–Like Illness with Infection-Induced or mRNA Vaccine-Induced SARS-CoV-2 Immunity — Nine States, January–September 2021
• Changing Features of COVID-19: Characteristics of Infections with the SARS-CoV-2 Delta (B.1.617.2) and Alpha (B.1.1.7) Variants in Southern Italy
• Partial resistance of SARS-CoV-2 Delta variants to vaccine-elicited antibodies and convalescent sera
• Seroprevalence of Antibodies to SARS-CoV-2 in Guangdong Province, China between March to June 2020
• Data-driven analysis of amino acid change dynamics timely reveals SARS-CoV-2 variant emergence
• Genetic Analysis of SARS-CoV-2 Variants in Mexico during the First Year of the COVID-19 Pandemic
• Nanoparticular CpG-adjuvanted SARS-CoV-2 S1 protein elicits broadly neutralizing and Th1-biased immunoreactivity in mice
• Genomic diversity of SARS-CoV-2 in Oxford during United Kingdom's first national lockdown
• Evaluation of Human Circulating T Follicular Helper Cells in Influenza-and SARS-CoV-2-Specific B Cell Immunity
• Adaptation, spread and transmission of SARS-CoV-2 in farmed minks and associated humans in the Netherlands
• Multiple introductions of SARS-CoV-2 B.1.1.214 lineages from mainland Japan preceded the third wave of the COVID-19 epidemic in Hokkaido
• Surges of hospital-based rhinovirus infection during the 2020 coronavirus disease-19 (COVID-19) pandemic in Beijing, China
• 感染了全球近1/3人口的弓形虫，会让人更易患上新冠吗？
• 基于棘突糖蛋白的SARS-CoV-2（新型冠状病毒）疫苗及新病毒变异的意义
• 迄今为止突变最严重的新冠变异株来了！有关奥密克戎的六个问题，一次性说清楚
• 当“新冠”遇上“艾滋”会发生什么？丨微生物的那些事儿
• 关于奥密克戎，国家卫健委权威解答来了！
• Enhanced fusogenicity and pathogenicity of SARS-CoV-2 Delta P681R mutation
• Genomic monitoring of the SARS-CoV-2 B1.1.7 (WHO VOC Alpha) in the Sao Paulo state, Brazil
• Head-to-head analysis of immunogenicity and reactogenicity of heterologous ChAdOx1 nCoV-19-priming and BNT162b2 or mRNA-1273-boosting with homologous COVID-19 vaccine regimens
• A Higher Antibody Response Is Generated With a 6- to 7-Week (vs Standard) Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Vaccine Dosing Interval
• Mucosal vaccination induces protection against SARS-CoV-2 in the absence of detectable neutralizing antibodies
• Limited and Short-Lasting Virus Neutralizing Titers Induced by Inactivated SARS-CoV-2 Vaccine
• Experimental and field investigations of exposure, replication and transmission of SARS-CoV-2 in pigs in the Netherlands
• 新冠病毒感染模型研究取得新进展
• Establishment of human distal lung organoids for SARS-CoV-2 infection
• Establishment of a humanized swine model for COVID-19
• Omicron的形势有多严峻？科学家已知多少？
• How bad is Omicron? What scientists know so far
• 准确率达95%！美科学家研发新设备 几乎即时检测出新冠等病毒
• 司书毅/陈云雨团队合作开发基于荧光偏振原理的新冠病毒主蛋白酶小分子抑制剂高效筛选关键技术平台
• Development of a simple and miniaturized sandwich-like fluorescence polarization assay for rapid screening of SARS-CoV-2 main protease inhibitors
• 科学家发现SARS-CoV-2病毒躲避免疫系统的运作机制
• 服务升级 ▏义翘神州推出Omicron突变株等新冠病毒相关技术服务，助力全球科技防疫
• 助力科研，义翘神州成功开发奥密克戎（Omicron）突变假病毒
• 哈工大马军院士——绿色消毒技术有效阻断新冠病毒“物传人”
• A third SARS-CoV-2 spike vaccination improves neutralization of variants-of-concern
• Live attenuated virus vaccine protects against SARS-CoV-2 variants of concern B. 1.1. 7 (Alpha) and B. 1.351 (Beta)
• Genomic evidence of SARS‐CoV‐2 reinfection in the Republic of Korea
• Evolution of SARS-CoV-2 Seroprevalence Among Employees of a United States Academic Children's Hospital During the COVID-19 Pandemic
• SARS-CoV-2 Seroprevalence in Florida Department of Health in Palm Beach County Obstetric Clinics: A Cross-Sectional Study during the First Pandemic Surge
• Nanoparticular CpG-adjuvanted SARS-CoV-2 S1 protein elicits broadly neutralizing and Th1-biased immunoreactivity in mice
• Comparison of the Development of SARS-Coronavirus-2-Specific Cellular Immunity, and Central Memory CD4+ T-Cell Responses Following Infection versus Vaccination
• Evaluation of different platforms for the detection of anti-SARS coronavirus-2 antibodies, Thailand
• Estimating the transmission advantage of the D614G mutant strain of SARS-CoV-2, December 2019 to June 2020
• Seroprevalence of IgG antibodies against SARS-CoV-2 among the general population and healthcare workers in India, June–July 2021: A population-based cross-sectional study
• 中山大学最新成果：99.9%相似性！突变特征追溯新冠病毒的自然宿主
• Mutation signatures inform the natural host of SARS-CoV-2
• Sci Adv：中大五院黄曦团队发现 TREM-2 识别新冠病毒并激活 T 细胞反应
• TREM-2 is a sensor and activator of T cell response in SARS-CoV-2 infection
• 香港大学发布预印本：奥密克戎在部分组织的繁殖速度比德尔塔快70倍！
• 美国污水厂检出奥密克戎病毒！一线人员如何做好防护？
• STTT | 突破！中山大学何欣/张辉首次揭示奥密克戎毒株表现出强大的免疫逃逸和病毒进入细胞能力
• SARS-CoV-2 Omicron strain exhibits potent capabilities for immune evasion and viral entrance
• Lancet Voice | 解读奥密克戎变异株
• Changing Features of COVID-19: Characteristics of Infections with the SARS-CoV-2 Delta (B. 1.617. 2) and Alpha (B. 1.1. 7) Variants in Southern Italy
• A Single mRNA vaccine dose in COVID-19 patients boosts neutralizing antibodies against SARS-CoV-2 and variants of concern
• Predominant airborne transmission and insignificant fomite transmission of SARS-CoV-2 in a two-bus COVID-19 outbreak originating from the same pre-symptomatic index case
• SARS-CoV-2 variants and their relevant mutational profiles: Update summer 2021
• SARS-CoV-2 ferritin nanoparticle vaccine induces robust innate immune activity driving polyfunctional spike-specific T cell responses
• Multiple introductions of SARS-CoV-2 B. 1.1. 214 lineages from mainland Japan preceded the third wave of the COVID-19 epidemic in Hokkaido
• Increased transmissibility of SARS-CoV-2 lineage B. 1.1. 7 by age and viral load
• Estimating the strength of selection for new SARS-CoV-2 variants
• Elapsed time since BNT162b2 vaccine and risk of SARS-CoV-2 infection: test negative design study
• Deciphering early-warning signals of SARS-CoV-2 elimination and resurgence from limited data at multiple scales
• Genome sequencing of SARS-CoV-2 reveals the prevalence of variant B 1.1. 7 in Egypt
• A Single Vaccine Protects against SARS-CoV-2 and Influenza Virus in Mice
• 奇迹！新冠变异株发现不到2个月，已有5篇Nature发表！ | 谢晓亮、何大一等评估奥密克戎对抗体和疫苗的抗性
• 清华成果 | 新型冠状病毒Omicron变异株刺突蛋白RBD与受体ACE2复合物晶体结构
• Nasal prevention of SARS-CoV-2 infection by intranasal influenza-based boost vaccination in mouse models
• Context-specific emergence and growth of the SARS-CoV-2 Delta variant
• Rapid test to assess the escape of SARS-CoV-2 variants of concern
• 郑春福教授在JMV上合作发表SARS-CoV-2最新研究进展综述
• Roles of thepolybasic furin cleavage site of spike protein in SARS-CoV-2 replication,pathogenesis, host immune responses, and vaccination
• 强强联合，清华大学王新泉和张林琦等揭示Omicron刺突蛋白RBD与受体ACE2复合物晶体结构
• PNAS|新冠病毒免疫逃逸重要“元凶”被发现—“细胞-细胞接触”传播
• SARS-CoV-2 spreads through cell-to-cell transmission
• 中科院钱文峰团队揭示：新冠Omicron毒株曾经历家鼠体内进化
• Omicron SARS-CoV-2 variant: a new chapter in the COVID-19 pandemic
• Escape from recognition of SARS-CoV-2 Beta variant spike epitopes but overall preservation of T cell immunity
• Enhanced fitness of SARS-CoV-2 variant of concern Alpha but not Beta
• Biparatopic nanobodies protect mice from lethal challenge with SARS-CoV-2 variants of concern
• 朱颖心：西安咸阳机场不存在“气动投毒”
• 新冠流感双重感染者早已出现！会带来“超级病毒”吗？
• bioRxiv | 突破！中科院徐华强/尹万超团队联合攻关新冠病毒奥密克戎变异株刺突蛋白及其与受体和抗病毒抗体的复合物结构
• Structures of the Omicron Spike trimer with ACE2 and an anti-Omicron antibody
• 哈工大马军院士团队Engineering：新冠病毒冷链物流全球传播挑战与多级绿色屏障疫情防控对策
• A Multi-Stage Green Barrier Strategy for the Control of Global SARS-CoV-2 Transmissionvia Cold Chain Goods
• STTT | 重大发现！徐志建/朱维良/宫丽崑发现奥密克戎传染性强是高免疫逃逸能力，但与结合ACE2亲和力比Delta变体弱
• SARS-CoV-2 Omicron RBD shows weaker binding affinity than the currently dominant Delta variant to human ACE2
• 国科大钱文峰研究员发现Omicron毒株经历家鼠体内进化
• Evidence for a mouse origin of the SARS-CoV-2 Omicron variant
• Immunity：新冠病毒抗原漂变比甲流病毒快10倍！| Cell Press论文速递
• Antigenic drift: Understanding COVID-19
• 口罩上持续存在新冠感染风险、人体中的“跳跃基因”︱BMC系列期刊月度热文
• 中山大学何欣/张辉团队联合报道新冠突变株Omicron对新冠患者康复血清具有极高的免疫逃逸能力并存在潜在高传播风险
• SARS-CoV-2 Omicron strain exhibits potent capabilities for immune evasion and viral entrance
• Cell: 王培毅/高福/齐建勋揭示新冠流行变异毒株Omicron和Delta入侵机制 | Cell Press对话科学家
• Receptor binding and complex structures of human ACE2 to spike RBD from Omicron and Delta SARS-CoV-2
• SARS-CoV-2新变异毒株出现，携带多达46个突变
• 双“毒”合一？塞浦路斯研究人员称发现“德尔塔克戎”毒株
• 毒王合二为一了？塞浦路斯发现德尔塔克戎deltacron
• International risk of SARS-CoV-2 Omicron variant importations originating in South Africa
• Neutralising reactivity against SARS-CoV-2 B. 1.617. 2 (Delta) variant by vaccination status and pre-exposure
• Prediction of SARS-CoV-2 Variant Lineages Using the S1-Encoding Region Sequence Obtained by PacBio Single-Molecule Real-Time Sequencing
• Infection with the SARS-CoV-2 Delta Variant is Associated with Higher Infectious Virus Loads Compared to the Alpha Variant in both Unvaccinated and Vaccinated Individuals
• Genetic analysis of a SARS-CoV-2 Omicron variant from a Chinese traveler returning from overseas
• 揭秘奥密克戎：它会是最后一个肆虐全球的新冠变体吗？
• Rapid and sensitive detection of SARS-CoV-2 variants in nasopharyngeal swabs and wastewaters
• 新冠Omicron变体（B.1.1.529）：传染性、疫苗突破和抗体耐药性
• Omicron (B.1.1.529): Infectivity, vaccine breakthrough, and antibody resistance
• 《柳叶刀》最新通讯文章 | 奥密克戎是不是SARS-CoV-2进化的突变极限？
• Reduced neutralisation of SARS-CoV-2 omicron B.1.1.529 variant by post-immunisation serum
• Nature|新冠变体Omicron对多数单克隆抗体有抗性，但加强疫苗可中和这种变体
• Considerable escape of SARS-CoV-2 Omicron to antibody neutralization
• 真的是感冒？袁国勇Nature:奥密克戎变异株毒力减弱、复制能力降低
• Attenuated replication and pathogenicity of SARS-CoV-2 B.1.1.529 Omicron
• Nature重磅，新冠大流行要终止？袁国勇院士团队发现奥密克戎的毒力和致病性大大下降
• Research|浙江大学那仁满都拉/许志宏发现热激可特异性降解新冠病毒RNA聚合酶并抑制病毒复制
• Heat Treatment Promotes Ubiquitin-Mediated Proteolysis of SARS-CoV-2 RNA Polymerase and Decreases Viral Load
• 北京大学谢晓亮团队在Nature/Cell等发表8篇文章，在新冠等领域取得重大突破
• Structural and functional characterizations of infectivity and immune evasion of SARS-CoV-2 Omicron
• 奥密克戎在小鼠中的复制和致病能力 |《自然》论文
• 奥密克戎在小鼠和仓鼠模型中致病性降低 |《自然》论文
• SARS-CoV-2 Omicron virus causes attenuated disease in mice and hamsters
• CDC和南开大学联合发现：新冠病毒Omicron变种可能由小鼠宿主进化而来
• Origin and evolutionary analysis of the SARS-CoV-2 Omicron variant
• 可能并不存在的超级变异株Deltacron
• Deltacron: the story of the variant that wasn’t
• 日本最新研究：奥密克戎变异毒株在塑料表面可存活193.5小时
• Cell Res║姜世勃/陆路/夏帅的EK1系列多肽能有效地抑制奥秘克戎真假病毒的感染
• Early signals of significantly increased vaccine breakthrough, decreased hospitalization rates, and less severe disease in patients with COVID-19 caused by the Omicron variant of SARS-CoV-2 in Houston, Texas
• From Delta to Omicron: analysing the SARS-CoV-2 epidemic in France using variant-specific screening tests (September 1 to December 18, 2021)
• Outcomes of laboratory-confirmed SARS-CoV-2 infection in the Omicron-driven fourth wave compared with previous waves in the Western Cape Province, South Africa
• Resilient T cell responses to B.1.1.529 (Omicron) SARS-CoV-2 variant
• Omicron (BA.1) SARS-CoV-2 variant is associated with reduced risk of hospitalization and length of stay compared with Delta (B.1.617.2)
• Identification of a novel SARS-CoV-2 P.1 sub-lineage in Brazil provides new insights about the mechanisms of emergence of variants of concern
• Cross reactivity of spike glycoprotein induced antibody against Delta and Omicron variants before and after third SARS-CoV-2 vaccine dose in healthy and immunocompromised individuals
• Striking Antibody Evasion Manifested by the Omicron Variant of SARS-CoV-2
• Omicron escapes the majority of existing SARS-CoV-2 neutralizing antibodies
• Anti-SARS-CoV-2 spike protein and neutralizing antibodies at 1 and 3 months after three doses of SARS-CoV-2 vaccine in a large cohort of solid organ transplant patients
• SARS-CoV-2 spike conformation determines plasma neutralizing activity
• Inactivated SARS-CoV-2 induces acute respiratory distress syndrome in human ACE2-transgenic mice
• Characterization of two SARS-CoV-2 subgenomic RNA dynamics in severe COVID-19 patients
• SARS-CoV-2 Omicron variant: Antibody evasion and cryo-EM structure of spike protein–ACE2 complex
• An infectious SARS-CoV-2 B.1.1.529 Omicron virus escapes neutralization by several therapeutic monoclonal antibodies
• Structural basis of SARS-CoV-2 Omicron immune evasion and receptor engagement
• Rapid detection and characterization of SARS-CoV-2 omicron variant in a returning traveler
• 新研究揭示新冠病毒感染和接种疫苗诱导抗体产生差异，BCR发挥重要作用
• B cell receptor repertoire kinetics after SARS-CoV-2 infection and vaccination
• 香港大学朱轩/陈福和/袁国勇团队揭示：奥密克戎变异株的复制能力及致病力下降 | Nature
• Attenuated replication and pathogenicity of SARS-CoV-2 B.1.1.529 Omicron
• 最新发现：患者同时感染两种SARS-CoV-2突变株还会发生基因重组
• Possible recombination between two variants of concern in a COVID-19 patient
• Science | 上海药物所徐华强/尹万超揭示奥密克戎变异株传播迅速和免疫逃逸的分子机制
• Structures of the Omicron Spike trimer with ACE2 and an anti-Omicron antibody
• Hypothesis: All respiratory viruses (including SARS-CoV-2) are aerosol-transmitted
• Differing kinetics of anti-spike protein IgGs and neutralizing antibodies against SARS-CoV-2 after Comirnaty (BNT162b2) immunization
• Molecular basis of cross-species ACE2 interactions with SARS-CoV-2-like viruses of pangolin origin
• Omicron variant susceptibility to neutralizing antibodies induced in children by natural SARS-CoV-2 infection or COVID-19 vaccine
• SARS-CoV-2 spike variants exhibit differential infectivity and neutralization resistance to convalescent or post-vaccination sera
• Survey of SARS‐CoV‐2 in dogs and cats in high‐risk areas during the second wave of COVID‐19 outbreak, Thailand
• Competitive Endogenous RNA Network Activates Host Immune Response in SARS-CoV-2-, panH1N1 (A/California/07/2009)-, and H7N9 (A/Shanghai/1/2013)-Infected Cells
• Signals of Significantly Increased Vaccine Breakthrough, Decreased Hospitalization Rates, and Less Severe Disease in Patients with Coronavirus Disease 2019 Caused by the Omicron Variant of Severe Acute Respiratory Syndrome Coronavirus 2 in Houston, Texas
• hnRNP C modulates MERS-CoV and SARS-CoV-2 replication by governing the expression of a subset of circRNAs and cognitive mRNAs
• Vaccines Elicit Highly Conserved Cellular Immunity to SARS-CoV-2 Omicron
• SARS-CoV-2 Omicron variant replication in human bronchus and lung ex vivo
• Altered TMPRSS2 usage by SARS-CoV-2 Omicron impacts tropism and fusogenicity
• Safety, mucosal and systemic immunopotency of an aerosolized adenovirus-vectored vaccine against SARS-CoV-2 in rhesus macaques
• SARS-CoV-2 Omicron Variant Neutralization in Serum from Vaccinated and Convalescent Persons
• Rapid detection and characterization of SARS-CoV-2 omicron variant in a returning traveler
• A human antibody reveals a conserved site on beta-coronavirus spike proteins and confers protection against SARS-CoV-2 infection
• Omicron的起源之谜︱《自然》长文
• Where did Omicron come from? Three key theories
• mBio | 陈宇/郭德银/Volker Thiel/Stanley Perlman揭示冠状病毒RNA甲基化逃逸天然免疫的新机制
• N7-Methylation of the Coronavirus RNA Cap Is Required for Maximal Virulence by Preventing Innate Immune Recognition
• Cell Reports| 新研究揭示新冠病毒感染和接种疫苗诱导抗体产生差异
• Cell重磅：粟硕/施莽团队揭示“野味”动物携带和人类疾病密切相关的多种病毒
• Virome characterization of game animals in China reveals a spectrum of emerging pathogens
• 曾木圣团队等揭示奥密克戎等新冠病毒关键突变株的抗原性改变和免疫逃逸特征
• Parallel profiling of antigenicity alteration and immune escape of SARS-CoV-2 Omicron and other variants
• 升级版Omicron导致更严重疾病？新研究敲响警钟
• Estimates of SARS-CoV-2 Omicron Variant Severity in Ontario, Canada
• First cases of Omicron in France are exhibiting mild symptoms, November 2021-January 2022
• The role of SARS-CoV-2 aerosol transmission during the COVID-19 pandemic
• Protection against the Omicron Variant from Previous SARS-CoV-2 Infection
• Protection against SARS-CoV-2 after Covid-19 Vaccination and Previous Infection
• Outbreak investigation of airborne transmission of Omicron (B.1.1.529) - SARS-CoV-2 variant of concern in a restaurant: Implication for enhancement of indoor air dilution
• The emergence, dynamics and significance of SARS-CoV-2 variants
• Generation time of the alpha and delta SARS-CoV-2 variants: an epidemiological analysis
• Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections by intranasal or testicular inoculation induces testicular damage preventable by vaccination in golden Syrian hamsters
• Safety, mucosal and systemic immunopotency of an aerosolized adenovirus-vectored vaccine against SARS-CoV-2 in rhesus macaques
• Severe acute respiratory disease in American mink (Neovison vison) experimentally infected with SARS-CoV-2